幽门螺杆菌和肠道寄生虫并发感染:黎巴嫩北部住院儿童和青少年的负担、社会人口和临床特征

Sara Mina, Sara Daher, Nour Mina, Ghalia Khoder
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摘要

背景幽门螺杆菌和肠道寄生虫是众所周知的儿童高发疾病,尤其是在发展中国家。然而,关于它们同时感染的记录却很少。在这项研究中,我们旨在评估黎巴嫩北部因上消化道不适而住院的儿童和青少年中肠道寄生虫与幽门螺杆菌之间的关联。方法 我们对 297 名年龄在 1-15 岁之间、有胃肠道症状的住院儿童患者进行了横断面研究。研究分析了所有参与者的社会人口学特征、生活方式和胃肠道特征。采集了新鲜粪便样本,并对其中是否存在肠道寄生虫和幽门螺杆菌感染进行了筛查。结果 6.4%的患者肠道寄生虫感染呈阳性,5.4%的患者幽门螺杆菌感染呈阳性,11.8%的患者合并感染。卡方检验结果显示,幽门螺杆菌感染与寄生虫感染有显著相关性,但与特定的寄生虫种类无关。最常见的合并感染是幽门螺杆菌-组织溶解酵母菌(77.1%)。此外,幽门螺杆菌感染与过度拥挤和进食前不经常清洗蔬菜有关。初等教育水平或更低的母亲的患者合并感染的比例更高。在临床特征方面,我们的研究结果表明,①胃反流与幽门螺杆菌,②严重腹泻与寄生虫感染之间存在统计学意义上的显著关系。结论 我们的数据强调了幽门螺杆菌与肠道寄生虫感染之间的关系。因此,在对儿童和青少年进行寄生虫感染筛查时,可以考虑检测幽门螺杆菌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Concomitant Infection of Helicobacter pylori and Intestinal Parasites: Burden, Sociodemographic and Clinical Characteristics in Hospitalized Children and Adolescents in Northern Lebanon
Background Helicobacter pylori and intestinal parasites are well-known for their high prevalence in children, especially in developing countries. However, their concomitant infections are poorly documented. In this study, we aimed to evaluate the association between intestinal parasites and H. pylori among hospitalized children and adolescents with upper gastrointestinal complaints in Northern Lebanon. Methods A cross-sectional study was conducted involving 297 hospitalized pediatric patients, aged between 1 and 15 years, who presented with gastrointestinal symptoms. The socio-demographic, lifestyle, and gastrointestinal characteristics of all participants were analyzed. Fresh stool samples were collected and screened for the presence of intestinal parasites and H. pylori infections. Results 6.4% of the patients were positive for intestinal parasitic infections, 5.4% were positive for H. pylori infection, and 11.8% were co-infected. The results of the Chi-square test showed that H. pylori infection is significantly associated with parasitic infection but not with a particular species. The most frequent coinfection was H. pylori-Entamoeba histolytica (77.1%). Moreover, H. pylori infection was associated with overcrowding and infrequent washing of vegetables before eating. The prevalence of co-infections increased in patients of mothers with a primary educational level or less. In regards to clinical characteristics, our findings showed a statistically significant relationship between i) gastric reflux and H. pylori, and ii) severe diarrhea and parasitic infection. Conclusion Our data highlighted the association between H. pylori and intestinal parasitic infections. Thus, H. pylori detection could be taken into consideration while screening for parasitic infections in children and adolescents.
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