纳米碳基光驱动疫苗对严重急性呼吸系统综合征冠状病毒 2 的免疫反应

Junming Chen, Qiang Wang, Fenfen Zhang, Jianshe Yang
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引用次数: 0

摘要

作为本世纪最严重的新型传染病,冠状病毒病2019(COVID-19)因药物和疫苗研发的滞后而面临巨大挑战。阐明冠状病毒与宿主免疫相互作用的全景机制是COVID-19疾病监测、诊断、治疗、预防和免疫评估的策略。基于碳纳米管(CNT)的光疫苗技术有助于解决这些挑战的核心科学问题。本视角阐述了基于碳纳米管的光疫苗的最新防控策略及其对高传播性和致病性变种的广谱抗性。此外,本视角还涵盖了在基于 CNT 的光疫苗干预下对严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)的潜在免疫反应,并最终评估了其功效和潜在的相互作用机制。未来,通过智能化学物理调控发现高效、保守的 T 细胞表位将为下一代疫苗的开发奠定良好基础。理想情况下,这些下一代疫苗应具有响应化学物理变化的动态异位功能,并呈现与病毒变异具有亲和力的异位表位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The immune response of nano carbon-based photic-driving vaccines to severe acute respiratory syndrome coronavirus 2
As the most severe novel infectious disease in this century, coronavirus disease 2019 (COVID-19) faces tremendous challenges due to the hysteresis of drugs and vaccine development. Elucidating the panoramic mechanism of coronavirus-host immune interaction is a strategy for disease surveillance, diagnosis, treatment, prevention, and immunity assessment of COVID-19. A robust carbon nanotube (CNT)-based photic vaccine technology contributes to address the core scientific issues of these challenges. This perspective states the latest prevention and control strategy of CNT-based photic vaccine and its broad-spectrum resistance to high transmissible and pathogenic variants. Furthermore, this perspective covers the potential immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) under the CNT-based photic vaccine intervention and finally evaluates its efficacy and the underlying interactive mechanisms. In the future, findings of the highly efficient and conservative T cell epitopes depending on an intelligent chem-physical modulation would provide a promising basis for the development of next generation vaccines. Ideally, these next generation vaccines are prone to be with the function of dynamic allostery responding to the chem-physical changing and present the allosteric epitopes which are affinity to the viral variation.
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