胆囊癌中雌激素受体α和孕激素受体的表达模式及其与临床病理参数和总生存期的关系

IF 1.6 Q4 ONCOLOGY
Journal of Gastrointestinal Cancer Pub Date : 2024-09-01 Epub Date: 2024-05-18 DOI:10.1007/s12029-024-01045-3
Sashibhusan Dash, Mamita Nayak, Sagarika Samantaray, Niranjan Rout, Manoranjan Ranjit
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引用次数: 0

摘要

背景:胆囊癌(GBC)是一种侵袭性极强的恶性肿瘤,预后极差。尽管胆囊癌早在两个世纪前就被首次描述,但除了传统的细胞毒疗法外,目前尚无其他靶向疗法。流行病学研究表明,女性胆囊癌的发病率高于男性。这表明胆囊可能是女性性激素反应器官,而这些激素可能与胆囊癌的发病机制有关。因此,我们旨在分析ERα和PR在GBC中的表达,并将其表达与临床病理变量和总生存率相关联:这项基于医院的横断面研究共纳入了235例经组织病理学诊断的GBC病例。收集了临床病理数据,并通过免疫组化评估了ERα和PR的表达:研究对象的平均年龄为(55.47 ± 8.45)岁,年龄范围为 28-87 岁。女性多于男性,男女比例为 1:3.5。ERα和PR的核阳性表达分别出现在13例(5.5%)和8例(3.4%)中。除细胞核染色外,ERα和PR的细胞质表达分别在3例(1.2%)和31例(13.2%)中发现。4例(P值=0.02)、pT晚期(T3)(P值=0.01)、淋巴管侵犯(P值=0.02)和肝脏侵犯(P值=0.04)的ER核阳性表达比例较高,具有统计学意义。结论中还观察到较高比例的 PR 表达:虽然ERα的核表达与疾病进展因素显著相关,但在极少数GBC病例中发现了阳性表达。因此,ERα阳性胆囊癌患者可以选择抗激素治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expression Pattern of Estrogen Receptor Alpha and Progesterone Receptor in Gallbladder Carcinoma and Their Association with Clinicopathological Parameters and Overall Survival.

Background: Gallbladder cancer (GBC) is a highly aggressive malignant tumor with a poor prognosis. Despite being first described two centuries ago, there are no targeted therapies available beyond conventional cytotoxic therapy. Epidemiological studies have shown that the incidence of gallbladder cancer is higher in females than males. This suggests that the gallbladder may be a female sex hormone-responsive organ, and these hormones might be involved in the pathogenesis of gallbladder cancer. Therefore, we aimed to analyze the expression of ERα and PR in GBC and correlate their expression with clinicopathological variables and overall survival.

Patients and methods: A total of 235 histopathologically diagnosed GBC cases were included in this hospital-based cross-sectional study. Clinicopathological data were collected, and the expression of ERα and PR was evaluated by immunohistochemistry.

Results: The mean age of this study population was 55.47 ± 8.45 with range 28-87 years. Females were predominated over male with a male-to-female ratio of 1:3.5. Positive nuclear expression of the ERα and PR was found in 13 (5.5%) and eight (3.4%) cases, respectively. Apart from nuclear staining, cytoplasmic expression of ERα and PR was found in three (1.2%) and 31 (13.2%) cases, respectively. Higher percentage of positive nuclear expression of ER was found in < 50 years age (p value = 0.04), parity > 4 (p value = 0.02), advanced pT stage (T3) (p value = 0.01), lymphovascular invasion (p value = 0.02), and liver invasion (p value = 0.04) which were statistically significant. Higher percentage of PR expression was also observed in < 50 years age (p value = 0.01), and tumor associated with gallstone (p value = 0.04). There was no significant correlation between cytoplasmic expression of ER, PR, and clinicopathological variables. In multivariate analysis, there was no significant correlation between ER or PR positive expression and overall survival.

Conclusion: Although nuclear expression of ERα was significantly associated with progressive disease factors but the positive expression was found in very small percentage of GBC cases. So anti-hormone therapy might be an option in patient with ER α positive gallbladder carcinoma.

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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
121
期刊介绍: The Journal of Gastrointestinal Cancer is a multidisciplinary medium for the publication of novel research pertaining to cancers arising from the gastrointestinal tract.The journal is dedicated to the most rapid publication possible.The journal publishes papers in all relevant fields, emphasizing those studies that are helpful in understanding and treating cancers affecting the esophagus, stomach, liver, gallbladder and biliary tree, pancreas, small bowel, large bowel, rectum, and anus. In addition, the Journal of Gastrointestinal Cancer publishes basic and translational scientific information from studies providing insight into the etiology and progression of cancers affecting these organs. New insights are provided from diverse areas of research such as studies exploring pre-neoplastic states, risk factors, epidemiology, genetics, preclinical therapeutics, surgery, radiation therapy, novel medical therapeutics, clinical trials, and outcome studies.In addition to reports of original clinical and experimental studies, the journal also publishes: case reports, state-of-the-art reviews on topics of immediate interest or importance; invited articles analyzing particular areas of pancreatic research and knowledge; perspectives in which critical evaluation and conflicting opinions about current topics may be expressed; meeting highlights that summarize important points presented at recent meetings; abstracts of symposia and conferences; book reviews; hypotheses; Letters to the Editors; and other items of special interest, including:Complex Cases in GI Oncology:  This is a new initiative to provide a forum to review and discuss the history and management of complex and involved gastrointestinal oncology cases. The format will be similar to a teaching case conference where a case vignette is presented and is followed by a series of questions and discussion points. A brief reference list supporting the points made in discussion would be expected.
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