Sangita Dey, Moodu Devender, Swati Rani, Rajan Kumar Pandey
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引用次数: 0
摘要
本书的这一章重点介绍了对癌症免疫疗法领域变革性创新的全面探索。CAR(嵌合抗原受体)T细胞疗法是一种突破性的癌症治疗方法,它通过重新编程患者的免疫细胞来识别和消灭癌细胞。本章强调了合成生物学在提高 CAR T 细胞疗法的安全性和有效性方面的关键作用。它首先强调了个性化医疗在癌症治疗中日益增长的重要性,强调了从 "一刀切 "的方法到针对患者的解决方案的转变。合成生物学是一个多学科领域,它在定制 CAR T 细胞疗法方面发挥了重要作用,可实现精确微调,最大限度地减少不必要的副作用。本章重点介绍了基因编辑、合成基因电路和分子工程的最新进展,展示了这些技术如何优化 CAR T 细胞的功能。总之,本书的这一章揭示了利用合成生物学开发 CAR T 细胞疗法所取得的显著进展,为癌症患者带来了希望,并预示着高度个性化和有效的癌症治疗将成为未来的常态。
Recent advances in CAR T-cell engineering using synthetic biology: Paving the way for next-generation cancer treatment.
This book chapter highlights a comprehensive exploration of the transformative innovations in the field of cancer immunotherapy. CAR (Chimeric Antigen Receptor) T-cell therapy represents a groundbreaking approach to treat cancer by reprogramming a patient immune cells to recognize and destroy cancer cells. This chapter underscores the critical role of synthetic biology in enhancing the safety and effectiveness of CAR T-cell therapies. It begins by emphasizing the growing importance of personalized medicine in cancer treatment, emphasizing the shift from one-size-fits-all approaches to patient-specific solutions. Synthetic biology, a multidisciplinary field, has been instrumental in customizing CAR T-cell therapies, allowing for fine-tuned precision and minimizing unwanted side effects. The chapter highlights recent advances in gene editing, synthetic gene circuits, and molecular engineering, showcasing how these technologies are optimizing CAR T-cell function. In summary, this book chapter sheds light on the remarkable progress made in the development of CAR T-cell therapies using synthetic biology, providing hope for cancer patients and hinting at a future where highly personalized and effective cancer treatments are the norm.
期刊介绍:
Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.