病毒感染在甲状腺癌进展中的潜在作用

IF 2.1 Q3 ONCOLOGY
World Journal of Oncology Pub Date : 2024-06-01 Epub Date: 2024-04-15 DOI:10.14740/wjon1830
Yong Ke Wu, Tian Tian Jiang, Yuan Hao Su, Lin Mei, Ting Kai Sun, Yun Hao Li, Zhi Dong Wang, Yuan Yuan Ji
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引用次数: 0

摘要

甲状腺癌(TC)的发病与多种因素有关。最近的研究表明,病毒感染可能是甲状腺癌发病机制中的一个关键因素。病毒,如爱泼斯坦-巴氏病毒(EBV)、丙型肝炎病毒(HCV)、人类免疫缺陷病毒(HIV)和严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2),可能在甲状腺癌的发生、发展甚至预后中起着至关重要的作用。本综述主要探讨了病毒感染在肺结核进展过程中的潜在作用。可能的机制包括:识别宿主细胞、与受体结合、影响癌基因水平、释放病毒产物形成有益环境、与免疫细胞相互作用诱导免疫逃避以及改变垂体-甲状腺轴。因此,全面的知识可为找到诊断和治疗与病毒有关的急性颅内感染的分子靶点提供启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Potential Role of Virus Infection in the Progression of Thyroid Cancer.

Multiple factors have engaged in the progression of thyroid cancer (TC). Recent studies have shown that viral infection can be a critical factor in the pathogenesis of TC. Viruses, such as Epstein-Barr virus (EBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may play an essential role in the occurrence, development, and even prognosis in TC. This review mainly explored the potential role of viral infection in the progress of TC. The possible mechanisms could be recognizing the host cell, binding to the receptors, affecting oncogenes levels, releasing viral products to shape a beneficial environment, interacting with immune cells to induce immune evasion, and altering the pituitary-thyroid axis. Thus, comprehensive knowledge may provide insights into finding molecular targets for diagnosing and treating virus-related TC.

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来源期刊
CiteScore
6.10
自引率
15.40%
发文量
37
期刊介绍: World Journal of Oncology, bimonthly, publishes original contributions describing basic research and clinical investigation of cancer, on the cellular, molecular, prevention, diagnosis, therapy and prognosis aspects. The submissions can be basic research or clinical investigation oriented. This journal welcomes those submissions focused on the clinical trials of new treatment modalities for cancer, and those submissions focused on molecular or cellular research of the oncology pathogenesis. Case reports submitted for consideration of publication should explore either a novel genomic event/description or a new safety signal from an oncolytic agent. The areas of interested manuscripts are these disciplines: tumor immunology and immunotherapy; cancer molecular pharmacology and chemotherapy; drug sensitivity and resistance; cancer epidemiology; clinical trials; cancer pathology; radiobiology and radiation oncology; solid tumor oncology; hematological malignancies; surgical oncology; pediatric oncology; molecular oncology and cancer genes; gene therapy; cancer endocrinology; cancer metastasis; prevention and diagnosis of cancer; other cancer related subjects. The types of manuscripts accepted are original article, review, editorial, short communication, case report, letter to the editor, book review.
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