Verteporfin (Visudyne®) 全球短缺的前景和最新情况。

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI:10.1007/s40123-024-00952-9

Marc J Sirks, Yousif Subhi, Noa Rosenberg, Carla E M Hollak, Camiel J F Boon, Roselie M H Diederen, Suzanne Yzer, Jeannette Ossewaarde-van Norel, Yvonne de Jong-Hesse, Reinier O Schlingemann, Rob J Moss, Elon H C van Dijk

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引用次数: 0

摘要

verteporfin（Visudyne®）在全球范围内的持续短缺限制了多种脉络膜视网膜疾病的治疗，包括中心性浆液性脉络膜视网膜病变、脉络膜血管瘤和多形性脉络膜血管病。对这些眼部疾病进行光动力治疗需要使用 Verteporfin。因此，目前的情况对全世界的眼科护理产生了重大影响。全球供应的 verteporfin 似乎是由位于美国的一家工厂生产的。verteporfin 由不同的公司分销到世界不同地区。负责的公司很少就短缺问题进行官方沟通，而且在过去几年中，有关解决短缺问题的几项承诺都没有兑现。新一批维替泊芬的交付间隔不定，无法预测，而且在世界不同地区或国家之间可能无法实现公平分配。为了确保在一个国家内公平分配可用的 verteporfin，可以采取几种措施。荷兰成立了一个由眼科医生组成的国家委员会来安排这项工作。在欧洲层面，欧盟和欧洲药品管理局计划更密切地监测药品短缺情况，并在必要时进行干预。通过加强对药品供应的监测和管理，可以防止未来即将发生的药品短缺。值得注意的是，药品短缺的数量正在不断增加，对病人护理产生了重大影响，有时甚至是不可逆转的影响。因此，应努力将后果降到最低，并尽可能防止未来出现药品短缺。

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Perspectives and Update on the Global Shortage of Verteporfin (Visudyne^®).

An ongoing global shortage of verteporfin (Visudyne^®) limits the treatment possibilities for several chorioretinal diseases, including central serous chorioretinopathy, choroidal hemangioma, and polypoidal choroidal vasculopathy. Verteporfin is required to perform photodynamic therapy in these ocular diseases. Therefore, the current situation has a substantial impact on eye care worldwide. The worldwide supply of verteporfin appears to be manufactured by a single factory, which is situated in the United States. The distribution of verteporfin is done by different companies for different regions of the world. Official communication on the shortage by the responsible companies has been scarce and over the past years several promises with regards to resolution of the shortage have not been fulfilled. The delivery of new batches of verteporfin is at irregular intervals, unpredictable, and may not be fairly balanced between different regions or countries in the world. To ensure a fair distribution of available verteporfin within a country, several measures can be taken. In the Netherlands, a national committee, consisting of ophthalmologists, is in place to arrange this. On the European level, the European Union and European Medicine Agency have plans to monitor medicine shortages more closely and to intervene if necessary. With a more intensified monitoring and regulation of medicine supplies, future impending shortages may be prevented. Remarkably, the amount of medicine shortages is increasing, having a significant and sometimes irreversible impact on patient care. Thus, efforts should be undertaken to minimize the consequences and, whenever possible, to prevent future medicine shortages.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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