如何利用空间 omics 方法绘制精神疾病中压力的生物影响图:视角、概述和技术指南。

IF 2.6 4区 心理学 Q2 BEHAVIORAL SCIENCES
Amber R Curry, Lezanne Ooi, Natalie Matosin
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引用次数: 0

摘要

终生暴露于巨大的压力和创伤之下是罹患主要精神疾病的主要风险因素。尽管如此,我们对压力如何增加精神障碍风险的机制还没有全面的了解。人体内的压力是复杂的,并根据压力类型、时间和持续时间的不同而产生不同的分子结果。因此,用迄今为止主要使用的传统单靶点实验方法来破解压力如何增加精神障碍的风险具有挑战性。重要的是,人们对应激后发生的分子过程尚未完全了解,但需要找到新的治疗靶点。以测序为基础的全局组学技术可以对应激引起的生理变化进行无偏见的研究,它正在以单细胞分辨率迅速加快我们对应激后遗症分子过程的了解。空间多组学技术目前也正在兴起,可同时分析从表观基因组到蛋白质组的功能分子层以及解剖学背景。这项技术具有巨大的潜力,可以改变我们对疾病如何发展的理解,我们相信这将极大地推动我们对特定风险因素(如压力)如何导致疾病进程的理解。在这里,我们从自己的角度阐述了我们认为这些技术将如何改变我们对压力神经生物学的理解,并提供了一份技术指南,以帮助希望在自己的研究中采用空间 omics 方法的分子精神病学和压力研究人员。最后,我们确定了在压力研究中使用多组学技术的潜在未来方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How spatial omics approaches can be used to map the biological impacts of stress in psychiatric disorders: a perspective, overview and technical guide.

Exposure to significant levels of stress and trauma throughout life is a leading risk factor for the development of major psychiatric disorders. Despite this, we do not have a comprehensive understanding of the mechanisms that explain how stress raises psychiatric disorder risk. Stress in humans is complex and produces variable molecular outcomes depending on the stress type, timing, and duration. Deciphering how stress increases disorder risk has consequently been challenging to address with the traditional single-target experimental approaches primarily utilized to date. Importantly, the molecular processes that occur following stress are not fully understood but are needed to find novel treatment targets. Sequencing-based omics technologies, allowing for an unbiased investigation of physiological changes induced by stress, are rapidly accelerating our knowledge of the molecular sequelae of stress at a single-cell resolution. Spatial multi-omics technologies are now also emerging, allowing for simultaneous analysis of functional molecular layers, from epigenome to proteome, with anatomical context. The technology has immense potential to transform our understanding of how disorders develop, which we believe will significantly propel our understanding of how specific risk factors, such as stress, contribute to disease course. Here, we provide our perspective of how we believe these technologies will transform our understanding of the neurobiology of stress, and also provided a technical guide to assist molecular psychiatry and stress researchers who wish to implement spatial omics approaches in their own research. Finally, we identify potential future directions using multi-omics technology in stress research.

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来源期刊
CiteScore
5.60
自引率
0.00%
发文量
25
审稿时长
6-12 weeks
期刊介绍: The journal Stress aims to provide scientists involved in stress research with the possibility of reading a more integrated view of the field. Peer reviewed papers, invited reviews and short communications will deal with interdisciplinary aspects of stress in terms of: the mechanisms of stressful stimulation, including within and between individuals; the physiological and behavioural responses to stress, and their regulation, in both the short and long term; adaptive mechanisms, coping strategies and the pathological consequences of stress. Stress will publish the latest developments in physiology, neurobiology, molecular biology, genetics research, immunology, and behavioural studies as they impact on the understanding of stress and its adverse consequences and their amelioration. Specific approaches may include transgenic/knockout animals, developmental/programming studies, electrophysiology, histochemistry, neurochemistry, neuropharmacology, neuroanatomy, neuroimaging, endocrinology, autonomic physiology, immunology, chronic pain, ethological and other behavioural studies and clinical measures.
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