Safak Akin, Pinar Ulgen, Busra Sen Yildirim, Eda Karaismailoglu, Ozhan Ozdemir, Nese Ersoz Gulcelik
{"title":"对三碘甲状腺原氨酸的中枢敏感性受损与妊娠糖尿病有关","authors":"Safak Akin, Pinar Ulgen, Busra Sen Yildirim, Eda Karaismailoglu, Ozhan Ozdemir, Nese Ersoz Gulcelik","doi":"10.1007/s13410-024-01347-z","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Thyroid hormones play an important role in the regulation of glucose metabolism. Recently, some studies determined the relationship between diabetes and abnormality of indices of thyroid hormone sensitivity. Thyroid dysfunction may play a role in the etiology of gestational diabetes mellitus (GDM).</p><h3 data-test=\"abstract-sub-heading\">Objective</h3><p>In the present study, we aim to determine central and peripheral thyroid hormone resistance by evaluating indices of thyroid hormone sensitivity and thyroid function tests and to investigate its effect on the etiology of GDM.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A total of 1416 euthyroid pregnant women were included in this study. Of these, 241 (17%) had GDM and 1175 (83%) did not have GDM. We evaluated the association of indices of sensitivity to thyroid hormones including TFQI<sub>FT4</sub>, TFQI<sub>FT3</sub>, TSHI, TT4RI, and FT3/FT4, with GDM in pregnant euthyroid women.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>We found higher FT3, TFQI<sub>FT3</sub>, and FT3/FT4 ratio in the GDM group. The present study also showed that significantly increased FT3 and TFQI<sub>FT3</sub> levels were associated with a higher risk of GDM after adjustment for potential confounding factors such as age and body mass index (BMI).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>FT3 and TFQI<sub>FT3</sub> were independently associated with the risk of GDM. The results of the present study may shed light on future studies by providing new information on the association of FT3 at the first antenatal visit with GDM.</p>","PeriodicalId":50328,"journal":{"name":"International Journal of Diabetes in Developing Countries","volume":"5 1","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impaired central sensitivity to triiodothyronine is associated with gestational diabetes mellitus\",\"authors\":\"Safak Akin, Pinar Ulgen, Busra Sen Yildirim, Eda Karaismailoglu, Ozhan Ozdemir, Nese Ersoz Gulcelik\",\"doi\":\"10.1007/s13410-024-01347-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Background</h3><p>Thyroid hormones play an important role in the regulation of glucose metabolism. Recently, some studies determined the relationship between diabetes and abnormality of indices of thyroid hormone sensitivity. Thyroid dysfunction may play a role in the etiology of gestational diabetes mellitus (GDM).</p><h3 data-test=\\\"abstract-sub-heading\\\">Objective</h3><p>In the present study, we aim to determine central and peripheral thyroid hormone resistance by evaluating indices of thyroid hormone sensitivity and thyroid function tests and to investigate its effect on the etiology of GDM.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>A total of 1416 euthyroid pregnant women were included in this study. Of these, 241 (17%) had GDM and 1175 (83%) did not have GDM. We evaluated the association of indices of sensitivity to thyroid hormones including TFQI<sub>FT4</sub>, TFQI<sub>FT3</sub>, TSHI, TT4RI, and FT3/FT4, with GDM in pregnant euthyroid women.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>We found higher FT3, TFQI<sub>FT3</sub>, and FT3/FT4 ratio in the GDM group. The present study also showed that significantly increased FT3 and TFQI<sub>FT3</sub> levels were associated with a higher risk of GDM after adjustment for potential confounding factors such as age and body mass index (BMI).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusions</h3><p>FT3 and TFQI<sub>FT3</sub> were independently associated with the risk of GDM. 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Impaired central sensitivity to triiodothyronine is associated with gestational diabetes mellitus
Background
Thyroid hormones play an important role in the regulation of glucose metabolism. Recently, some studies determined the relationship between diabetes and abnormality of indices of thyroid hormone sensitivity. Thyroid dysfunction may play a role in the etiology of gestational diabetes mellitus (GDM).
Objective
In the present study, we aim to determine central and peripheral thyroid hormone resistance by evaluating indices of thyroid hormone sensitivity and thyroid function tests and to investigate its effect on the etiology of GDM.
Methods
A total of 1416 euthyroid pregnant women were included in this study. Of these, 241 (17%) had GDM and 1175 (83%) did not have GDM. We evaluated the association of indices of sensitivity to thyroid hormones including TFQIFT4, TFQIFT3, TSHI, TT4RI, and FT3/FT4, with GDM in pregnant euthyroid women.
Results
We found higher FT3, TFQIFT3, and FT3/FT4 ratio in the GDM group. The present study also showed that significantly increased FT3 and TFQIFT3 levels were associated with a higher risk of GDM after adjustment for potential confounding factors such as age and body mass index (BMI).
Conclusions
FT3 and TFQIFT3 were independently associated with the risk of GDM. The results of the present study may shed light on future studies by providing new information on the association of FT3 at the first antenatal visit with GDM.
期刊介绍：
International Journal of Diabetes in Developing Countries is the official journal of Research Society for the Study of Diabetes in India. This is a peer reviewed journal and targets a readership consisting of clinicians, research workers, paramedical personnel, nutritionists and health care personnel working in the field of diabetes. Original research articles focusing on clinical and patient care issues including newer therapies and technologies as well as basic science issues in this field are considered for publication in the journal. Systematic reviews of interest to the above group of readers are also accepted.
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