对尼日利亚西南部常见草药和香料（油辣木叶、大蒜和红豆杉叶）的体外抗氧化活性、总酚和元素含量的评估

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Pure and Applied Chemistry Pub Date : 2024-05-08 DOI:10.1515/pac-2023-1128

Bukunola Oluyemisi Adegbesan, Esther Nkechi Ezima, Basit Opeyemi Hassan, Jeremiah Oluwasegun Kehinde, Aderinsola Ayoyemi Adewale, Ifabunmi Oduyemi Osonuga, Samuel Oluwadare Olalekan

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引用次数: 0

摘要

天然疗法被广泛用于治疗一些疾病，包括癌症、糖尿病、神经退行性疾病、动脉粥样硬化、高血压和其他心血管疾病。药用植物和香料在控制疾病方面的治疗作用怎么强调都不为过，但这些草药和植物的确切作用模式尚未完全阐明。这项研究工作旨在通过不同的化学方法，研究选定元素锌（Zn）、铁（Fe）、铜（Cu）、硒（Se）、铅（Pb）和镉（Cd）的表达；研究辣木叶、大蒜（Allium sativum）和香桃叶（Momordica charantia）乙醇提取物的植物化学成分和体外抗氧化特性，以了解它们在预防和治疗心血管疾病和癌症方面的潜在作用。通过研究 2,2-二苯基-2-吡啶-肼（DPPH）自由基清除潜能和铁还原抗氧化潜能（FRAP），对体外抗氧化特性进行了测定；使用 Folin-Ciocalteu 分析法测定了总酚含量；使用电感耦合等离子体光学发射光谱法（ICP-OES）研究了这些提取物的元素含量。所有试验均采用三重法进行分析。我们的研究结果表明，油橄榄叶、大蒜和香椿叶的乙醇提取物具有显著的抗氧化活性，并含有重要的有益元素（微量和痕量）和植物化学物质。这些结果表明，这些植物的药用特性可能与其乙醇提取物的自由基清除能力、有益元素和植物化学物质表达有关，这可能是药物发现和开发领域的一个良好方向。

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Evaluation of in vitro antioxidant activities, total phenolic and elemental contents of common herbs and spices (Moringa oleifera leaves, Allium sativum (Garlic) and Momordica charantia (ejinrin) leaves) in South-West Nigeria

Natural remedies are being widely utilized in some disease’s conditions including cancer, diabetes, neurodegenerative diseases, atherosclerosis hypertension and other cardiovascular diseases. The therapeutic intervention of medicinal plants and spices cannot be overemphasized in the management and control of diseases but the exact modes of action of these herbs and plants have not been fully elucidated. This research work was designed to study the expression of selected elements, zinc (Zn), iron (Fe), copper (Cu), selenium (Se), lead (Pb) and cadmium (Cd); the phytochemical and the in vitro antioxidant properties of ethanolic extracts of Moringa oleifera leaves, Allium sativum (Garlic) and Momordica charantia (ejinrin) leaves for their potential involvement in the prevention and management of cardiovascular diseases and cancer through different chemical methods. In vitro antioxidant properties were assayed by investigating 2,2-diphenyl-2-picryl-hydrazyl (DPPH) free radicals scavenging potentials and Ferric Reducing Antioxidant Potential (FRAP); total phenolic content was determined by using Folin-Ciocalteu assay and the elemental contents of these extracts was investigated through the use of Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). All tests were run in triplicates and analysed. Our results revealed that the ethanolic extracts of M. oleifera leaves, A. sativum (Garlic) and M. charantia (ejinrin) leaves possess significant antioxidant activities and express important and beneficial elements (in marginal and trace amounts) and phytochemicals. These results suggest that the medicinal attributes of these plants may be linked to the radical scavenging abilities, beneficial elements and phytochemicals expression of their ethanolic extracts which may likely be a good direction in the area of drug discovery and development.

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来源期刊

Pure and Applied Chemistry 化学-化学综合

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： Pure and Applied Chemistry is the official monthly Journal of IUPAC, with responsibility for publishing works arising from those international scientific events and projects that are sponsored and undertaken by the Union. The policy is to publish highly topical and credible works at the forefront of all aspects of pure and applied chemistry, and the attendant goal is to promote widespread acceptance of the Journal as an authoritative and indispensable holding in academic and institutional libraries.