Theresa Kirchner, George N. Dalekos, Kalliopi Zachou, Mercedes Robles-Díaz, Raúl J. Andrade, Marcial Sebode, Ansgar Lohse, Maciej K. Janik, Piotr Milkiewicz, Mirjam Kolev, Nasser Semmo, Tony Bruns, Tom Jg Gevers, Benedetta Terziroli Beretta-Piccoli, Heiner Wedemeyer, Elmar Jaeckel, Richard Taubert, Bastian Engel, pIgG study group
{"title":"免疫介导的肝损伤中多反应性免疫球蛋白 G 的升高与免疫抑制疗法的必要性","authors":"Theresa Kirchner, George N. Dalekos, Kalliopi Zachou, Mercedes Robles-Díaz, Raúl J. Andrade, Marcial Sebode, Ansgar Lohse, Maciej K. Janik, Piotr Milkiewicz, Mirjam Kolev, Nasser Semmo, Tony Bruns, Tom Jg Gevers, Benedetta Terziroli Beretta-Piccoli, Heiner Wedemeyer, Elmar Jaeckel, Richard Taubert, Bastian Engel, pIgG study group","doi":"10.1101/2024.05.04.24306873","DOIUrl":null,"url":null,"abstract":"<strong>Background and aim</strong> The distinction of drug-induced liver injury (DILI), drug-induced autoimmune-like hepatitis (DI-ALH) and autoimmune hepatitis (AIH) can be challenging due to overlapping clinical characteristics. Recently, polyreactive immunoglobulin G (pIgG) was identified as a novel biomarker with a higher accuracy for the diagnose of AIH than conventional autoantibodies. This retrospective multicenter study aimed to evaluate the diagnostic accuracy of pIgG to distinguish between AIH, DI-ALH and DILI and thus identify patients in need of immunosuppression.","PeriodicalId":501258,"journal":{"name":"medRxiv - Gastroenterology","volume":"33 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Elevated polyreactive immunoglobulin G in immune mediated liver injuries with the need for immunosuppressive therapy\",\"authors\":\"Theresa Kirchner, George N. Dalekos, Kalliopi Zachou, Mercedes Robles-Díaz, Raúl J. Andrade, Marcial Sebode, Ansgar Lohse, Maciej K. Janik, Piotr Milkiewicz, Mirjam Kolev, Nasser Semmo, Tony Bruns, Tom Jg Gevers, Benedetta Terziroli Beretta-Piccoli, Heiner Wedemeyer, Elmar Jaeckel, Richard Taubert, Bastian Engel, pIgG study group\",\"doi\":\"10.1101/2024.05.04.24306873\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>Background and aim</strong> The distinction of drug-induced liver injury (DILI), drug-induced autoimmune-like hepatitis (DI-ALH) and autoimmune hepatitis (AIH) can be challenging due to overlapping clinical characteristics. Recently, polyreactive immunoglobulin G (pIgG) was identified as a novel biomarker with a higher accuracy for the diagnose of AIH than conventional autoantibodies. This retrospective multicenter study aimed to evaluate the diagnostic accuracy of pIgG to distinguish between AIH, DI-ALH and DILI and thus identify patients in need of immunosuppression.\",\"PeriodicalId\":501258,\"journal\":{\"name\":\"medRxiv - Gastroenterology\",\"volume\":\"33 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Gastroenterology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.05.04.24306873\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Gastroenterology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.05.04.24306873","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Elevated polyreactive immunoglobulin G in immune mediated liver injuries with the need for immunosuppressive therapy
Background and aim The distinction of drug-induced liver injury (DILI), drug-induced autoimmune-like hepatitis (DI-ALH) and autoimmune hepatitis (AIH) can be challenging due to overlapping clinical characteristics. Recently, polyreactive immunoglobulin G (pIgG) was identified as a novel biomarker with a higher accuracy for the diagnose of AIH than conventional autoantibodies. This retrospective multicenter study aimed to evaluate the diagnostic accuracy of pIgG to distinguish between AIH, DI-ALH and DILI and thus identify patients in need of immunosuppression.
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