基于 OCT 的近视儿童黄斑曲率评估及其与黄斑微血管的关系

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-07-01 Epub Date: 2024-05-14 DOI:10.1007/s40123-024-00956-5

Yue Wu, Xin Liu, Yuying Liu, Wenzhe Qian, Liandi Huang, Yixiang Wu, Xuetong Wang, Ying Yuan, Bilian Ke

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引用次数: 0

摘要

简介目的：评估基于光学相干断层扫描（OCT）的黄斑曲率指数（MCI）在近视儿童中的眼内差异，并研究MCI与黄斑微血管之间的关系：52名斜视度数大于2.00 D的学龄儿童接受了全面检查，包括屈光度数、轴向长度（AL）和扫描源OCT/OCT血管造影。通过 MATLAB R2022 中的自定义曲线拟合模型，在眼窝处直径为 1 毫米、3 毫米和 6 毫米的圆圈处从水平和垂直 B 扫描中确定了基于 OCT 的 MCI。分析了 MCI 的特征和地形变化，并研究了其与微血管及其相关因素的关系：MCI具有很高的可靠性和可重复性。在眼窝处直径为 1 毫米、3 毫米和 6 毫米的圆周上，近视度数较高的眼睛的 MCI 总体上大于近视度数较低的眼睛（均为 p 结论：在眼窝处直径为 1 毫米、3 毫米和 6 毫米的圆周上，近视度数较高的眼睛的 MCI 总体上大于近视度数较低的眼睛：近视度数较高的近视眼MCI较大，且与较小的DCP密度显著相关，表明MCI是近视相关视网膜微血管变化的重要指标，可作为儿童近视评估的重要指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Assessment of OCT-Based Macular Curvature and Its Relationship with Macular Microvasculature in Children with Anisomyopia.

查看原文本刊更多论文

Assessment of OCT-Based Macular Curvature and Its Relationship with Macular Microvasculature in Children with Anisomyopia.

Introduction: To evaluate the intraocular differences in optical coherence tomography (OCT)-based macular curvature index (MCI) among children with anisomyopia and to investigate the relationship between MCI and the macular microvasculature.

Methods: Fifty-two schoolchildren with anisometropia > 2.00 D were enrolled and underwent comprehensive examinations including cycloplegic refraction, axial length (AL), and swept source OCT/OCT angiography. OCT-based MCIs were determined from horizontal and vertical B-scans by a customized curve fitting model in MATLAB R2022 at 1-mm-, 3-mm-, and 6-mm-diameter circles at fovea. Characteristics and topographic variation of MCI was analyzed, and the relationships with microvascularity and its associated factors were investigated.

Results: MCI achieved high reliability and repeatability. There were overall larger MCIs in the more myopic eyes than the less myopic eyes in 1-mm-, 3-mm-, and 6-mm-diameter circles at fovea (all p < 0.001). For the topographic variation, horizontal MCI was significantly greater than vertical MCI (all p < 0.001), and was the largest in 6-mm circle, followed by 3-mm and 1-mm circles. Stronger correlation of horizontal MCI with myopic severity than vertical MCI was found. Partial Pearson's correlation found MCI was negatively associated with deep capillary plexus (DCP) vessel density (p = 0.016). Eyes with a higher MCI in a 6-mm circle were more likely to have longer AL (p < 0.001), lower DCP vessel density (p = 0.037), and thinner choroidal thickness (ChT) (p = 0.045).

Conclusion: Larger MCI was found in the more myopic eyes of children with anisomyopia and was significantly associated with smaller DCP density, suggesting that MCI was an important indicator of myopia-related retinal microvascularity change, and it could be a valuable metric for myopia assessment in children.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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