重症患者在医院获得的细菌性肺炎:从研究到临床实践。

IF 4.2 2区 医学 Q1 INFECTIOUS DISEASES
Pompeo Costantino Kouroupis, Niall O'Rourke, Sinead Kelly, Myles McKittrick, Elne Noppe, Luis F Reyes, Alejandro Rodriguez, Ignacio Martin-Loeches
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引用次数: 0

摘要

简介:医院获得性肺炎(HAP医院获得性肺炎(HAP)是导致重症监护病房(ICU)重症患者死亡的一个重要原因。为了提高疗效和改善患者预后,及时准确的诊断势在必行。然而,诊断过程面临着检验局限性和广泛的鉴别诊断清单的挑战,尤其是在患者表现出氧需求增加、白细胞增多和分泌物增多的情况下:本叙述性综述旨在更新诊断方法,以便及时识别非典型肺炎,同时指导、制定和评估治疗干预措施。我们利用 MEDLINE/PubMed 数据库对 2013 年至 2024 年 4 月期间的文献进行了全面综述:整合临床、微生物学和影像学工具的综合方法至关重要。诊断技术(包括新型分子方法)的进步、床旁超声波的使用和准确性的提高、人工智能的出现,再加上对肺部微生物群和宿主-病原体相互作用的进一步了解,不断增强了我们准确、迅速地识别 HAP 及其致病因子的能力。这一进步有助于完善治疗策略,促进精准医疗方法的实施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hospital-acquired bacterial pneumonia in critically ill patients: from research to clinical practice.

Introduction: Hospital-acquired pneumonia (HAP) represents a significant cause of mortality among critically ill patients admitted to Intensive Care Units (ICUs). Timely and precise diagnosis is imperative to enhance therapeutic efficacy and patient outcomes. However, the diagnostic process is challenged by test limitations and a wide-ranging list of differential diagnoses, particularly in patients exhibiting escalating oxygen requirements, leukocytosis, and increased secretions.

Areas covered: This narrative review aims to update diagnostic modalities, facilitating the prompt identification of nosocomial pneumonia while guiding, developing, and assessing therapeutic interventions. A comprehensive literature review was conducted utilizing the MEDLINE/PubMed database from 2013 to April 2024.

Expert opinion: An integrated approach that integrates clinical, microbiological, and imaging tools is paramount. Progress in diagnostic techniques, including novel molecular methods, the expanding utilization and accuracy of bedside ultrasound, and the emergence of Artificial Intelligence, coupled with an improved comprehension of lung microbiota and host-pathogen interactions, continues to enhance our capability to accurately and swiftly identify HAP and its causative agents. This advancement enables the refinement of treatment strategies and facilitates the implementation of precision medicine approaches.

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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
66
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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