多发性骨髓瘤并发轻链铸型肾病伴局灶性淀粉样变性：病例报告。

IF 2.4 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephrology Pub Date : 2024-10-01 Epub Date: 2024-05-14 DOI:10.1111/nep.14315

Yicao He, Zhijuan Hua, Hu Tan, Congjuan Zhao, Qiang Liu, Juan Jia, Yan Gao

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引用次数: 0

摘要

本病例报告描述了一例罕见而有趣的多发性骨髓瘤患者并发轻链（LC）铸型肾病和局灶性淀粉样变性的病例。患者出现急性肾损伤、贫血和骨骼病变。骨髓活检、血清和尿液电泳以及肾活检证实了这一诊断。患者接受了异唑米、泊马度胺和地塞米松联合化疗，随后进行了自体干细胞移植。患者的临床症状得到缓解，肾功能稳定，血清游离λ-LC水平有所改善。该病例凸显了诊断和治疗这种疾病所面临的挑战和取得的进展。

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Multiple myeloma complicated with light chain cast nephropathy with focal amyloidosis: A case report.

This case report describes a rare and interesting case of a patient with multiple myeloma complicated with light chain (LC) cast nephropathy and focal amyloidosis. The patient presented with acute kidney injury, anaemia and bone lesions. The diagnosis was confirmed by bone marrow biopsy, serum and urine electrophoresis and kidney biopsy. The patient was treated with isazomil, pomalidomide and dexamethasone combination chemotherapy, followed by autologous stem cell transplantation. The patient achieved clinical remission, stable renal function and improved serum lambda free LC levels. This case highlights the challenges and advances in the diagnosis and treatment of this condition.

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来源期刊

Nephrology 医学-泌尿学与肾脏学

CiteScore

4.50

自引率

4.00%

发文量

128

审稿时长

4-8 weeks

期刊介绍： Nephrology is published eight times per year by the Asian Pacific Society of Nephrology. It has a special emphasis on the needs of Clinical Nephrologists and those in developing countries. The journal publishes reviews and papers of international interest describing original research concerned with clinical and experimental aspects of nephrology.