Arzoe Singh, Rahul Khanna, Annya Suman, Jack Pollack, Sudhir Sekhsaria
{"title":"胃食管反流病与哮喘控制的关系。","authors":"Arzoe Singh, Rahul Khanna, Annya Suman, Jack Pollack, Sudhir Sekhsaria","doi":"10.1080/20018525.2024.2348267","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To study whether ACT responses are confounded by gastro-esophageal status (GERD), and if this is in concordance with the variation in Forced Expiratory Volume in 1 second (FEV1%) and Fractional Excretion of Nitric Oxide (FeNO).</p><p><strong>Materials and methods: </strong>This is a prospective cohort study (<i>n</i> = 307). Patients were surveyed for demographics data, and underwent ACT scoring, FEV1% and FeNO testing.</p><p><strong>Results: </strong>Patients with GERD had mean ACT scores that were 4.1 (<i>p</i> < .001) lower than without-GERD group. Not-well-controlled asthmatics (FEV1% <80, high FeNO) with-GERD had mean ACT scores that were 2.9 (<i>p</i> < .001) for FEV1% <80 and 3.8 (<i>p</i> = .008) for high FeNO lower than without-GERD group respectively. Well-controlled asthmatics (FEV1% ≥80, low FeNO) with-GERD had mean ACT scores that were 5.2 (<i>p</i> < .001) for FEV1% ≥80 and 5.1 (<i>p</i> < .001) for low FeNO lower than without-GERD group respectively.</p><p><strong>Conclusion: </strong>Our study demonstrates that symptoms of GERD can lead to an inaccurate perception of asthma control and ACT as compared to objective measures, such as FEV1% and FeNO. Hence, this can lead to mismanagement of asthma, especially when objective measures are not conducted along with ACT.</p>","PeriodicalId":11872,"journal":{"name":"European Clinical Respiratory Journal","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11089934/pdf/","citationCount":"0","resultStr":"{\"title\":\"The relationship of gastroesophageal reflux disease and asthma control.\",\"authors\":\"Arzoe Singh, Rahul Khanna, Annya Suman, Jack Pollack, Sudhir Sekhsaria\",\"doi\":\"10.1080/20018525.2024.2348267\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To study whether ACT responses are confounded by gastro-esophageal status (GERD), and if this is in concordance with the variation in Forced Expiratory Volume in 1 second (FEV1%) and Fractional Excretion of Nitric Oxide (FeNO).</p><p><strong>Materials and methods: </strong>This is a prospective cohort study (<i>n</i> = 307). Patients were surveyed for demographics data, and underwent ACT scoring, FEV1% and FeNO testing.</p><p><strong>Results: </strong>Patients with GERD had mean ACT scores that were 4.1 (<i>p</i> < .001) lower than without-GERD group. Not-well-controlled asthmatics (FEV1% <80, high FeNO) with-GERD had mean ACT scores that were 2.9 (<i>p</i> < .001) for FEV1% <80 and 3.8 (<i>p</i> = .008) for high FeNO lower than without-GERD group respectively. Well-controlled asthmatics (FEV1% ≥80, low FeNO) with-GERD had mean ACT scores that were 5.2 (<i>p</i> < .001) for FEV1% ≥80 and 5.1 (<i>p</i> < .001) for low FeNO lower than without-GERD group respectively.</p><p><strong>Conclusion: </strong>Our study demonstrates that symptoms of GERD can lead to an inaccurate perception of asthma control and ACT as compared to objective measures, such as FEV1% and FeNO. Hence, this can lead to mismanagement of asthma, especially when objective measures are not conducted along with ACT.</p>\",\"PeriodicalId\":11872,\"journal\":{\"name\":\"European Clinical Respiratory Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-05-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11089934/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Clinical Respiratory Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/20018525.2024.2348267\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Clinical Respiratory Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/20018525.2024.2348267","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
The relationship of gastroesophageal reflux disease and asthma control.
Purpose: To study whether ACT responses are confounded by gastro-esophageal status (GERD), and if this is in concordance with the variation in Forced Expiratory Volume in 1 second (FEV1%) and Fractional Excretion of Nitric Oxide (FeNO).
Materials and methods: This is a prospective cohort study (n = 307). Patients were surveyed for demographics data, and underwent ACT scoring, FEV1% and FeNO testing.
Results: Patients with GERD had mean ACT scores that were 4.1 (p < .001) lower than without-GERD group. Not-well-controlled asthmatics (FEV1% <80, high FeNO) with-GERD had mean ACT scores that were 2.9 (p < .001) for FEV1% <80 and 3.8 (p = .008) for high FeNO lower than without-GERD group respectively. Well-controlled asthmatics (FEV1% ≥80, low FeNO) with-GERD had mean ACT scores that were 5.2 (p < .001) for FEV1% ≥80 and 5.1 (p < .001) for low FeNO lower than without-GERD group respectively.
Conclusion: Our study demonstrates that symptoms of GERD can lead to an inaccurate perception of asthma control and ACT as compared to objective measures, such as FEV1% and FeNO. Hence, this can lead to mismanagement of asthma, especially when objective measures are not conducted along with ACT.
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