颌下腺慢性硬化性颌下腺炎及其 IgG4 相关疾病的组织病理学特征:17 例系列病例。

IF 3.2 Q2 PATHOLOGY
Vinícius Rio Verde Melo Muniz, Albina Altemani, Valéria Souza Freitas, Bruno Cunha Pires, Dandara Andrade de Santana, Larissa Abbehusen Couto, Maria Cristina Teixeira Cangussu, Ricardo Santiago Gomez, Suzana Catanhede Orsine Machado de Souza, Pablo Augustin Vargas, Patrícia Ramos Cury, Iguaracyra Barreto de Araújo, Roberta Rayra Martins Chaves, Felipe Paiva Fonseca, Jean Nunes Dos Santos
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引用次数: 0

摘要

目的:本研究旨在描述慢性硬化性咽鼓管炎的组织病理学免疫组化特征,强调 IgG4 相关疾病:方法:对 17 例慢性硬化性咽鼓管炎病例进行组织病理学检查(炎症、纤维化、腺实质和淋巴滤泡)和免疫组化检查(BCL2、CD3、CD20、CD34、CD163、p63、细胞周期蛋白 D1、肥大细胞、SMA、S100A4、IgG 和 IgG4),并进行评分。对与 IgG4 相关的疾病特征进行了调查。此外,还收集了人口统计学和临床数据:男性居多(10:7),平均病变大小为 3.9 厘米。常见的组织病理学发现包括尖状体实质减少、淋巴滤泡形成和导管增生。CD3阳性的T淋巴细胞以及CD34和SMA阳性的基质成纤维细胞大量存在。9个病例(53%)出现霰粒肿,3个病例符合IgG4相关疾病的标准:结论:颌下腺 CSS 代表的是一种反应性模式,而非 IgG4-RD,因为只有 3 个病例似乎与 IgG4-RD 有关。免疫组化图谱显示,大量 CD3 阳性 T 淋巴细胞与细胞周期蛋白 D1 等调节蛋白相反,这表明 CD34- 和 SMA 阳性基质成纤维细胞群促成了 CSS 的纤维化特征。此外,我们的研究结果为研究 CSS 及其与 IgG4-RD 的关系提供了一个全面的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chronic Sclerosing Sialadenitis of the Submandibular Gland and its Histopathological Spectrum in the IgG4-Related Disease: a Series of 17 Cases.

Purpose: This study aimed to characterize the histopathological immunohistochemical features of chronic sclerosing sialadenitis, emphasizing the IgG4-related disease.

Methods: Seventeen cases of chronic sclerosing sialoadenitis were examined for histopathological aspects, (inflammation, fibrosis, glandular parenchyma, and lymphoid follicles) and immunohistochemistry (BCL2, CD3, CD20, CD34, CD163, p63, cyclin D1, mast cell, SMA, S100A4, IgG, and IgG4) which were scored. IgG4-related disease features were investigated. Demographic and clinical data were also collected.

Results: Males predominated (10:7), with an average lesion size of 3.9 cm. Common histopathological findings included reduced acinar parenchyma, lymphoid follicle formation, and ductular proliferation. CD3-positive T lymphocytes and CD34- and SMA-positive stromal fibroblasts were abundant. Nine cases (53%) showed sialoliths and three cases met the criteria for IgG4-related disease.

Conclusion: CSS of the submandibular gland represents a reactive pattern rather than IgG4-RD as only 3 cases seemed to be related to IgG4-RD. The immunohistochemical profile revealed an abundant population of CD3-positive T lymphocytes, as opposed to regulatory proteins such as cyclin D1, demonstrating that populations of CD34- and SMA-positive stromal fibroblasts contribute to the fibrosis characteristic of CSS. In addition, our results provide a comprehensive insight into the study of CSS and its relationship with IgG4-RD.

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来源期刊
CiteScore
5.70
自引率
9.50%
发文量
99
期刊介绍: Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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