人类朊病毒疾病对生化生物标志物的需求尚未得到满足。

IF 1.9 3区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prion Pub Date : 2024-12-01 Epub Date: 2024-05-12 DOI:10.1080/19336896.2024.2349017

Peter Hermann, Inga Zerr

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引用次数: 0

摘要

尽管聚集检测方法的开发明显提高了朊病毒疾病临床诊断的准确性，但生物标志物的研究仍然至关重要。需要克服的主要挑战是非侵入性采样和探索可预测发病或反映疾病进展的新生物标志物。在不久的将来，当新的疗法经过临床评估并最终可用于治疗时，这将变得极为重要。本文旨在概述人类朊病毒疾病生物标志物研究的成就，探讨该领域尚未满足的需求，并展望未来。

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Unmet needs of biochemical biomarkers for human prion diseases.

Although the development of aggregation assays has noticeably improved the accuracy of the clinical diagnosis of prion diseases, research on biomarkers remains vital. The major challenges to overcome are non-invasive sampling and the exploration of new biomarkers that may predict the onset or reflect disease progression. This will become extremely important in the near future, when new therapeutics are clinically evaluated and eventually become available for treatment. This article aims to provide an overview of the achievements of biomarker research in human prion diseases, addresses unmet needs in the field, and points out future perspectives.

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来源期刊

Prion 生物-生化与分子生物学

CiteScore

5.20

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Prion is the first international peer-reviewed open access journal to focus exclusively on protein folding and misfolding, protein assembly disorders, protein-based and structural inheritance. The goal is to foster communication and rapid exchange of information through timely publication of important results using traditional as well as electronic formats. The overriding criteria for publication in Prion are originality, scientific merit and general interest.