从多中心角度看诱导青春期的雌二醇和孕激素制剂的供应、使用和偏好。

IF 2.6 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Aneta M Gawlik-Starzyk, Małgorzata Więcek, Debbie Matthews, Berit Öhman Kriström, Janielle A E M van der Velden, Theo C J Sas, Malgorzata Wasniewska, Siska Verlinde, Caroline Brain, Arlene Smyth, Malcolm David Cairns Donaldson
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引用次数: 0

摘要

导言:口服或透皮 17β-estradiol 天然雌激素被推荐用于性腺功能低下女孩的青春期诱导。然而,合适的低剂量制剂在全球范围内并不普遍。这项问卷调查旨在了解目前全球雌激素和孕酮制剂的供应情况:方法:经ESPE特纳综合征工作组批准,问卷调查的对象是儿科内分泌专家。问题主要涉及口服/透皮 17β-estradiol 和孕激素制剂的可及性。2020 年 6 月至 2022 年 12 月期间,通过 ESPE 渠道、直接外联和会议传播的 SurveyMonkey 调查收集了答复:参与调查的包括来自 45 个国家的 229 名医疗保健专业人员。成人剂量的口服和透皮 17β-estradiol 非常容易获得(86.5% 和 84.3%),透皮给药是首选形式(62.8%)。最常见的雌二醇制剂包括 50 微克贴片(32 个国家)和 1 或 2 毫克片剂(65.8% 和 71.1% 的国家)。然而,在 8 个国家的受访者中,只有 20% 的受访者能买到 0.5 毫克的 17β-estradiol 片剂。每天服用 14 或 25 微克 17β-estradiol 的贴剂分别在 3 个和 20 个国家有售。口服孕激素的可获得性(96.0%)和偏好性(87.0%)都很广泛,而透皮使用仅限于 15.2% 的受访者:这项研究凸显了全球在获取合适的女性青春期诱导激素制剂方面所面临的挑战。在大多数国家,雌二醇贴片的最低剂量为 50 微克,片剂为 2 毫克。合适的低剂量 17β-estradiol 片剂比低剂量贴剂更难获得。我们的调查强调了根据当地供应情况调整指南的重要性,以及改善可及性以解决这些全球差异的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Availability, Usage, and Preferences of Estradiol and Progestogen Preparations for Puberty Induction from a Multicentral Perspective.

Introduction: Natural oestrogen administration as oral or transdermal 17β-estradiol is recommended for pubertal induction in girls with hypogonadism. However, suitable low-dose formulations are not consistently available globally. This questionnaire study aimed to identify the current availability of oestrogen and progesterone preparations worldwide.

Methods: Endorsed by the ESPE Turner Syndrome Working Group, the questionnaire targeted paediatric endocrinologists. Questions focused on accessibility of oral/transdermal 17β-estradiol and progestogen preparations. Responses were collected through a SurveyMonkey survey disseminated via ESPE channels, direct outreach, and conferences from June 2020 to December 2022.

Results: Participation included 229 healthcare professionals from 45 countries. Oral and transdermal 17β-estradiol in adult dosage was highly accessible (86.5% and 84.3%), with transdermal administration the preferred form (62.8%). Most commonly available estradiol preparations included 50 μg patches (32 countries) and 1 or 2 mg tablets (65.8% and 71.1% countries). However, 0.5 mg 17β-estradiol tablets were available in only 20% of respondents from 8 countries. Patches delivering 14 or 25 μg/day of 17β-estradiol were available in 3 and 20 countries, respectively. Oral progestogen had widespread availability (96.0%) and preference (87.0%), while transdermal usage was limited to 15.2% of respondents.

Conclusion: This study highlights global challenges in accessing suitable hormone preparations for female pubertal induction. In most countries, the lowest dose of the estradiol is 50 µg for patches and 2 mg for tablets. Appropriate low-dose 17β-estradiol tablets are much less available than low-dose patches. Our survey underscores the importance of adapting guidelines to local availability, and the need for improved accessibility to address these global disparities.

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来源期刊
Hormone Research in Paediatrics
Hormone Research in Paediatrics ENDOCRINOLOGY & METABOLISM-PEDIATRICS
CiteScore
4.90
自引率
6.20%
发文量
88
审稿时长
4-8 weeks
期刊介绍: The mission of ''Hormone Research in Paediatrics'' is to improve the care of children with endocrine disorders by promoting basic and clinical knowledge. The journal facilitates the dissemination of information through original papers, mini reviews, clinical guidelines and papers on novel insights from clinical practice. Periodic editorials from outstanding paediatric endocrinologists address the main published novelties by critically reviewing the major strengths and weaknesses of the studies.
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