Mahdie Hosseini, Jayaram K. Udupa, You Hao, Yubing Tong, Caiyun Wu, Yusuf Akhtar, Mostafa Al-Noury, Shiva Shaghaghi, Joseph M. McDonough, David M. Biko, Samantha Gogel, Oscar H. Mayer, Patrick J. Cahill, Drew A. Torigian, Jason B. Anari
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Assessment of 3D hemi-diaphragmatic motion via free-breathing dynamic MRI in pediatric thoracic insufficiency syndrome
Purpose Thoracic insufficiency syndrome (TIS) affects ventilatory function due to spinal and thoracic deformities limiting lung space and diaphragmatic motion. Corrective orthopedic surgery can be used to help normalize skeletal anatomy, restoring lung space and diaphragmatic motion. This study employs free-breathing dynamic MRI (dMRI) and quantifies the 3D motion of each hemi-diaphragm surface in normal and TIS patients, and evaluates effects of surgical intervention.
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