三卤代异氰尿酸:卤化反应和杂环支架构建的有用试剂

IF 1.7 3区 化学 Q3 CHEMISTRY, ORGANIC
Marcio C. S. de Mattos
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引用次数: 0

摘要

:三卤代异氰尿酸[1,3,5-三卤-1,3,5-三嗪-2,4,6-(1H,3H,5H)-三酮]是市售或易于制备的固体。它们具有高活性、稳定性和易处理性,并具有出色的原子经济性,可将多达三个卤素原子转移到有机底物上。因此,本综述总结了它们作为安全、方便试剂的合成应用。因此,本综述介绍并讨论了烯、炔、炔烃、杂烯、羰基化合物和杂原子的亲电卤化反应,以及涉及饱和底物的自由基卤化反应和阿贝尔型反应的原位卤化中间体。值得注意的是,还介绍了三卤代异氰尿酸在基于亲电卤化和氧化环化、多组分反应和伸缩反应的杂芳烃支架构建过程中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trihaloisocyanuric Acids: Useful Reagents for Halogenation Reactions and Heterocyclic Scaffold Construction
: Trihaloisocyanuric acids [1,3,5-trihalo-1,3,5-triazine-2,4,6-(1H,3H,5H)-triones] are commercially available or easily prepared solids. They are highly reactive, stable, easily handled, and have an excellent atom economy, transferring up to three halogen atoms to organic substrates. In these regards, the present review summarizes their synthetic applications as safe and convenient reagents. Therefore, electrophilic halogenation reactions of alkenes, alkynes, arenes, heteroarenes, carbonyl compounds, and heteroatoms, as well as radical halogenation involving saturated substrates and in situ halogenated intermediates for Appel-type reactions are presented and discussed. Remarkably, applications of trihaloisocyanuric acids in processes for the construction of heteroarene scaffolds based on electrophilic halo- and oxidative cyclization, multicomponent reactions, and telescopic reactions are also given.
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来源期刊
Current Organic Chemistry
Current Organic Chemistry 化学-有机化学
CiteScore
3.70
自引率
7.70%
发文量
76
审稿时长
1 months
期刊介绍: Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.
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