利用氨基末端前脑钠肽标记物预测小儿风湿性心脏病二尖瓣反流严重程度和左心室扩张程度

Q3 Medicine

International Journal of Critical Illness and Injury Science Pub Date : 2024-01-01 Epub Date: 2024-03-27 DOI:10.4103/ijciis.ijciis_54_23

Dyahris Koentartiwi, Kurniawan Taufiq Kadafi, Fiqi Isnaini Nurul Hikmah, Takhta Khalasha, Ardhanis Ramadhanti, Renny Suwarniaty

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引用次数: 0

摘要

背景：早期风湿性心脏病（RHD）的特点是瓣膜反流，导致心室胀大，并可能产生氨基末端前脑钠尿肽（NT-proBNP）：方法：31 名患有 RHD 的儿童参加了研究。所有患者均接受了经胸超声心动图检查，以评估瓣膜疾病的严重程度和心脏功能，并因此分为三组：轻度、中度和重度二尖瓣反流（MR），伴有或不伴有左心室（LV）扩张。在进行回声检查时，抽取静脉血样本，然后使用夹心免疫测定法测定 NT-proBNP 水平：结果：轻度、中度和重度 MR 的 NT-proBNP 水平中位数分别为 32.34、120.75 和 7094 pg/ml。有左心室扩张和无左心室扩张患者的中位 NT-proBNP 水平分别为 3045 和 30.82 pg/ml。MR 的严重程度与 NT-proBNP 水平之间存在明显的相关性（P < 0.001），因此左心室扩张与 NT-proBNP 水平之间也存在明显的相关性（P = 0.013）。以 2598.50 pg/ml 为临界值，NT-proBNP 水平对重度 MR 的敏感性为 90%，特异性为 90.5%。NT-proBNP 水平的临界值为 199.35 pg/ml，对左心室扩张的敏感性为 73.3%，特异性为 75%。NT-proBNP水平的临界值为2598.50 pg/ml，对左心室扩张的重度MR的敏感性为85.7%，特异性为79.2%：结论：NT-proBNP水平与RHD患儿MR和左心室扩张的严重程度有明显关系。

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Predictor of mitral valve regurgitation severity and left ventricular dilatation using amino-terminal pro-brain natriuretic peptide marker in pediatric rheumatic heart disease.

Background: Early rheumatic heart disease (RHD) is characterized by valve regurgitation, leading to ventricular distention and possible elaboration of amino-terminal pro-brain natriuretic peptide (NT-proBNP).

Methods: Thirty-one children with RHD were entered in the study. Transthoracic echocardiography was performed in all patients to assess the severity of the valve disease and cardiac function, thus will be classified into three groups: mild, moderate, and severe mitral valve regurgitation (MR), with and without left ventricular (LV) dilatation. At the time of echo, venous blood samples were drawn; thus, NT-proBNP levels were measured using sandwich immunoassay.

Results: The median NT-proBNP levels in mild, moderate, and severe MR were 32.34, 120.75, and 7094 pg/ml, respectively. The median NT-proBNP levels in patients with and without LV dilatation were 3045 and 30.82 pg/ml. There was a significant correlation between the severity of MR and NT-proBNP levels (P < 0.001), thus a significant correlation between LV dilatation and NT-proBNP levels (P = 0.013). A cutoff value of 2598.50 pg/ml was obtained with a sensitivity value of 90% and a specificity of 90.5% for NT-proBNP levels against severe MR. A cutoff value of 199.35 pg/ml was obtained with a sensitivity value of 73.3% and a specificity of 75% for NT-proBNP levels on LV dilatation. A cutoff value of 2598.50 pg/ml was obtained with a sensitivity value of 85.7% and a specificity of 79.2% for NT-proBNP levels against severe MR with LV dilatation.

Conclusion: There was a significant relationship between NT-proBNP levels and the severity of MR and LV dilatation in children with RHD.

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来源期刊

International Journal of Critical Illness and Injury Science Medicine-Emergency Medicine

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： IJCIIS encourages research, education and dissemination of knowledge in the field of Critical Illness and Injury Science across the world thus promoting translational research by striking a synergy between basic science, clinical medicine and public health. The Journal intends to bring together scientists and academicians in the emergency intensive care and promote translational synergy between Laboratory Science, Clinical Medicine and Public Health. The Journal invites Original Articles, Clinical Investigations, Epidemiological Analysis, Data Protocols, Case Reports, Clinical Photographs, review articles and special commentaries. Students, Residents, Academicians, Public Health experts and scientists are all encouraged to be a part of this initiative by contributing, reviewing and promoting scientific works and science.