Evelyn Calderon-Martinez, Diana Gavilanes, Esmeralda Vilchez, Adalberto Guzman, Wern Ng, Christian Zevallos-Delgado, Anas Atrash
{"title":"类风湿性关节炎及其对炎症性肠病的影响。","authors":"Evelyn Calderon-Martinez, Diana Gavilanes, Esmeralda Vilchez, Adalberto Guzman, Wern Ng, Christian Zevallos-Delgado, Anas Atrash","doi":"10.14740/jocmr5121","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The association between inflammatory bowel disease (IBD) and arthritis has long been known, but it was not until the 1950s that IBD-associated arthritis was recognized as a distinct pathology independent from rheumatoid arthritis (RA). There is evidence that RA and other autoimmune conditions exist at higher rates in patients with IBD compared to the general population. We aimed to determine if the presence of RA in IBD patients is a factor for mortality and IBD-related surgery in this population.</p><p><strong>Methods: </strong>Using Epic's Slicer Dicer function, we queried the International Classification of Diseases, 10th Revision (ICD-10) codes K50 and K51 to identify patients with IBD. Duplicates and those with incomplete information were excluded, leaving a total of 3,613 patients. Data collected included basic demographic information, surgical history, and the presence of RA. We used Student's <i>t</i>-test to analyze between group differences for the continuous variables. When it was determined that variances for the comparisons of continuous data were unequal, Welch-Satterthwaite <i>t</i>-test statistics were used. We used the Chi-square test to analyze between group differences for the categorical variables. The Fisher's exact test was employed when any of the expected frequencies was 5 or less. All tests were two-sided with criterion for statistical significance at a P value less than 0.05. All the analyses were done by SAS 9.4 (SAS Institute, Cary, NC).</p><p><strong>Results: </strong>Of the approximately 2.7 million adults in Slicer Dicer, there were 3,613 patients (0.13%) identified with IBD. Patients with ulcerative colitis (UC) accounted for 37% of the total group (n = 1,343) and 2,270 patients (62.8%) had Crohn's disease (CD). From the total, 2,084 were women (57.68%) and 1,529 (42.32%) were men. More than 90% of the patients were white (n = 3,321). The mean age was 53.3 ± 18.5. Eight hundred forty-eight patients (23.47%) had documented RA. Mortality was higher in patients with IBD and RA than those with IBD alone (7.31% vs. 3.98%, P value ≤ 0.0001).</p><p><strong>Conclusions: </strong>IBD patients with RA have higher mortality rates and need for IBD-related surgery than patients with IBD alone.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"16 4","pages":"170-173"},"PeriodicalIF":1.6000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073383/pdf/","citationCount":"0","resultStr":"{\"title\":\"Rheumatoid Arthritis and Its Implications on Inflammatory Bowel Disease.\",\"authors\":\"Evelyn Calderon-Martinez, Diana Gavilanes, Esmeralda Vilchez, Adalberto Guzman, Wern Ng, Christian Zevallos-Delgado, Anas Atrash\",\"doi\":\"10.14740/jocmr5121\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The association between inflammatory bowel disease (IBD) and arthritis has long been known, but it was not until the 1950s that IBD-associated arthritis was recognized as a distinct pathology independent from rheumatoid arthritis (RA). There is evidence that RA and other autoimmune conditions exist at higher rates in patients with IBD compared to the general population. We aimed to determine if the presence of RA in IBD patients is a factor for mortality and IBD-related surgery in this population.</p><p><strong>Methods: </strong>Using Epic's Slicer Dicer function, we queried the International Classification of Diseases, 10th Revision (ICD-10) codes K50 and K51 to identify patients with IBD. Duplicates and those with incomplete information were excluded, leaving a total of 3,613 patients. Data collected included basic demographic information, surgical history, and the presence of RA. We used Student's <i>t</i>-test to analyze between group differences for the continuous variables. When it was determined that variances for the comparisons of continuous data were unequal, Welch-Satterthwaite <i>t</i>-test statistics were used. We used the Chi-square test to analyze between group differences for the categorical variables. The Fisher's exact test was employed when any of the expected frequencies was 5 or less. All tests were two-sided with criterion for statistical significance at a P value less than 0.05. All the analyses were done by SAS 9.4 (SAS Institute, Cary, NC).</p><p><strong>Results: </strong>Of the approximately 2.7 million adults in Slicer Dicer, there were 3,613 patients (0.13%) identified with IBD. Patients with ulcerative colitis (UC) accounted for 37% of the total group (n = 1,343) and 2,270 patients (62.8%) had Crohn's disease (CD). From the total, 2,084 were women (57.68%) and 1,529 (42.32%) were men. More than 90% of the patients were white (n = 3,321). The mean age was 53.3 ± 18.5. Eight hundred forty-eight patients (23.47%) had documented RA. 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引用次数: 0
摘要
背景：炎症性肠病（IBD）与关节炎之间的关联早已为人所知，但直到 20 世纪 50 年代，IBD 相关性关节炎才被认为是一种独立于类风湿性关节炎（RA）的独特病理。有证据表明，与普通人群相比，IBD 患者中患 RA 和其他自身免疫性疾病的比例更高。我们的目的是确定 IBD 患者中是否存在 RA 是影响该人群死亡率和 IBD 相关手术的一个因素：我们使用 Epic 的 Slicer Dicer 功能查询了《国际疾病分类》第十版（ICD-10）代码 K50 和 K51，以确定 IBD 患者。剔除了重复和信息不完整的患者，总共有 3,613 名患者。收集的数据包括基本人口统计学信息、手术史和是否患有 RA。我们使用学生 t 检验来分析连续变量的组间差异。当确定连续数据比较的方差不相等时，我们使用韦尔奇-萨特斯韦特 t 检验统计。我们使用卡方检验来分析分类变量的组间差异。当任何一个预期频率为 5 或 5 以下时，我们采用费雪精确检验。所有检验均为双侧检验，统计显著性标准为 P 值小于 0.05。所有分析均由 SAS 9.4（SAS Institute，Cary，NC）完成：在 Slicer Dicer 的约 270 万成年人中，有 3613 名患者（0.13%）被确认患有 IBD。溃疡性结肠炎（UC）患者占总人数（1343 人）的 37%，克罗恩病（CD）患者有 2270 人（62.8%）。其中，2,084 名患者为女性（57.68%），1,529 名患者为男性（42.32%）。90%以上的患者为白人（n = 3,321）。平均年龄为 53.3 ± 18.5 岁。848名患者（23.47%）有RA记录。IBD合并RA患者的死亡率高于单纯IBD患者（7.31% vs. 3.98%，P值≤0.0001）：结论：合并 RA 的 IBD 患者的死亡率和 IBD 相关手术的需求均高于单纯 IBD 患者。
Rheumatoid Arthritis and Its Implications on Inflammatory Bowel Disease.
Background: The association between inflammatory bowel disease (IBD) and arthritis has long been known, but it was not until the 1950s that IBD-associated arthritis was recognized as a distinct pathology independent from rheumatoid arthritis (RA). There is evidence that RA and other autoimmune conditions exist at higher rates in patients with IBD compared to the general population. We aimed to determine if the presence of RA in IBD patients is a factor for mortality and IBD-related surgery in this population.
Methods: Using Epic's Slicer Dicer function, we queried the International Classification of Diseases, 10th Revision (ICD-10) codes K50 and K51 to identify patients with IBD. Duplicates and those with incomplete information were excluded, leaving a total of 3,613 patients. Data collected included basic demographic information, surgical history, and the presence of RA. We used Student's t-test to analyze between group differences for the continuous variables. When it was determined that variances for the comparisons of continuous data were unequal, Welch-Satterthwaite t-test statistics were used. We used the Chi-square test to analyze between group differences for the categorical variables. The Fisher's exact test was employed when any of the expected frequencies was 5 or less. All tests were two-sided with criterion for statistical significance at a P value less than 0.05. All the analyses were done by SAS 9.4 (SAS Institute, Cary, NC).
Results: Of the approximately 2.7 million adults in Slicer Dicer, there were 3,613 patients (0.13%) identified with IBD. Patients with ulcerative colitis (UC) accounted for 37% of the total group (n = 1,343) and 2,270 patients (62.8%) had Crohn's disease (CD). From the total, 2,084 were women (57.68%) and 1,529 (42.32%) were men. More than 90% of the patients were white (n = 3,321). The mean age was 53.3 ± 18.5. Eight hundred forty-eight patients (23.47%) had documented RA. Mortality was higher in patients with IBD and RA than those with IBD alone (7.31% vs. 3.98%, P value ≤ 0.0001).
Conclusions: IBD patients with RA have higher mortality rates and need for IBD-related surgery than patients with IBD alone.
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