含五种草药提取物的口服溶液治疗尿路结石的疗效:随机、单盲、安慰剂对照临床试验。

IF 0.8 Q4 PHARMACOLOGY & PHARMACY
Journal of Research in Pharmacy Practice Pub Date : 2024-04-30 eCollection Date: 2023-07-01 DOI:10.4103/jrpp.jrpp_11_24
Sahand Samandarian, Rasool Soltani, Valiollah Hajhashemi, Mehdi Dehghani, Mohammad Matinfar, Mohaddese Mahboubi, Afsaneh Mohsenzadeh
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引用次数: 0

摘要

目的:泌尿系统结石的发病率高且易复发,因此需要制备一种副作用最小的高效药物。在传统医学中,刺蒺藜、荨麻、茵陈、玉米须和瓜果是治疗尿路结石的草药。本研究旨在评估这些植物提取物治疗尿路结石的效果:在一项随机、单盲、安慰剂对照临床试验中,符合纳入标准的参与者被随机分配到药物组(n = 27)和安慰剂组(n = 27),分别服用草药或安慰剂溶液,剂量为每日 3 次,每次 60 滴,持续 4 周,同时接受标准治疗。干预前后,测量了 24 小时尿量、24 小时尿液中钙、钠、柠檬酸盐、草酸盐、尿素、肌酐和尿酸的含量以及尿液 pH 值。通过超声波检查确定结石的数量和大小(直径为毫米),并记录每位患者的检查结果:结果:除 24 小时尿量外,干预结束时其他尿液参数与基线相比没有明显变化。此外,两组患者在这些指标上也没有明显差异。在结石参数方面,与安慰剂组相比,药物组的结石体积明显缩小(P = 0.049)。药物组完全排出结石的病例数明显高于安慰剂组(分别为 12 例和 4 例,P = 0.017):结论:口服草药溶液可使泌尿系统结石患者的结石缩小并排出。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of an Oral Solution Containing Five Herbal Extracts in the Treatment of Urolithiasis: A Randomized, Single-blind, Placebo-controlled Clinical Trial.

Objective: The high prevalence of urolithiasis and its recurrence entail the preparation of an efficient drug with the least side effects. Tribulus terrestris, Urtica dioica, Adiantum capillus-veneris, Stigma maydis (corn silk), and Cucumis melo are herbal remedies utilized in traditional medicine for urolithiasis. This study aimed to assess the efficiency of these plants' extracts in treating urolithiasis.

Methods: In a randomized, single-blind, placebo-controlled clinical trial, participants meeting inclusion criteria were randomly allocated to the drug (n = 27) and placebo (n = 27) groups to take herbal or placebo solutions, respectively, at a dose of 60 drops 3 times daily for 4 weeks with standard treatment. Before and after the intervention, 24-h urine volume and the quantities of calcium, sodium, citrate, oxalate, urea, creatinine, and uric acid in 24-h urine, and urinary pH were measured. The number and size (diameter in mm) of stones were determined by ultrasonography and recorded for each patient.

Findings: Except for 24 h urine volume, other urinary parameters did not alter significantly at the end of the intervention compared to baseline. Furthermore, the two groups had no significant difference regarding these indices. Regarding stone parameters, the stone size decreased significantly in the drug group compared to the placebo group (P = 0.049). The number of cases with complete stone expulsion in the drug group was significantly higher than in the placebo group (12 cases vs. 4 cases, respectively, P = 0.017).

Conclusion: Oral consumption of the herbal solution causes stone size reduction and stone expulsion in patients with urolithiasis.

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来源期刊
Journal of Research in Pharmacy Practice
Journal of Research in Pharmacy Practice PHARMACOLOGY & PHARMACY-
自引率
0.00%
发文量
8
审稿时长
21 weeks
期刊介绍: The main focus of the journal will be on evidence-based drug-related medical researches (with clinical pharmacists’ intervention or documentation), particularly in the Eastern Mediterranean region. However, a wide range of closely related issues will be also covered. These will include clinical studies in the field of pharmaceutical care, reporting adverse drug reactions and human medical toxicology, pharmaco-epidemiology and toxico-epidemiology (poisoning epidemiology), social aspects of pharmacy practice, pharmacy education and economic evaluations of treatment protocols (e.g. cost-effectiveness studies). Local reports of medication utilization studies at hospital or pharmacy levels will only be considered for peer-review process only if they have a new and useful message for the international pharmacy practice professionals and readers.
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