Alexandra Bonmatí-Santané, Roberto Céspedes López, Jehimy Jean Alvarez Saltos, Jordi Calabia Martínez, Cristina Noboa Paez, Jordi Piedra Sánchez, Natalia Visa Figueredo, Anna Maroto González
{"title":"管理出现罕见血型抗体 PP1Pk 的孕妇。","authors":"Alexandra Bonmatí-Santané, Roberto Céspedes López, Jehimy Jean Alvarez Saltos, Jordi Calabia Martínez, Cristina Noboa Paez, Jordi Piedra Sánchez, Natalia Visa Figueredo, Anna Maroto González","doi":"10.1089/whr.2023.0120","DOIUrl":null,"url":null,"abstract":"<p><p>Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%-70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis.</p>","PeriodicalId":75329,"journal":{"name":"Women's health reports (New Rochelle, N.Y.)","volume":"5 1","pages":"319-323"},"PeriodicalIF":1.6000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11002322/pdf/","citationCount":"0","resultStr":"{\"title\":\"Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk.\",\"authors\":\"Alexandra Bonmatí-Santané, Roberto Céspedes López, Jehimy Jean Alvarez Saltos, Jordi Calabia Martínez, Cristina Noboa Paez, Jordi Piedra Sánchez, Natalia Visa Figueredo, Anna Maroto González\",\"doi\":\"10.1089/whr.2023.0120\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%-70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis.</p>\",\"PeriodicalId\":75329,\"journal\":{\"name\":\"Women's health reports (New Rochelle, N.Y.)\",\"volume\":\"5 1\",\"pages\":\"319-323\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11002322/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Women's health reports (New Rochelle, N.Y.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1089/whr.2023.0120\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Women's health reports (New Rochelle, N.Y.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/whr.2023.0120","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk.
Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%-70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
