Diaspora 人类基因组研究所发起 "携手变革 "倡议:史无前例的技术进步时代,确保健康公平的变革性历史伙伴关系。

IF 1.2 4区 医学 Q4 HEALTH POLICY & SERVICES
James E K Hildreth, Anil Shanker
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引用次数: 0

摘要

目前,人体研究、药物和设备开发主要以非西班牙裔白人的基因数据为基础,有色人种被排除在外。这种做法使有色人种在接受疾病、残疾和疾病治疗时处于明显的、潜在的致命劣势,正如在 COVID-19 大流行期间所看到的那样。包括癌症在内的所有慢性疾病都存在重大差异。数据显示,目前研究的基因信息中,只有不到 2% 来自非洲裔。如果基因组数据集不能充分代表有色人种,那么新药和基因疗法可能无法像对欧洲人后裔那样奏效。要解决历史上被边缘化的人群可能再次被排除在影响人类健康的下一次技术飞跃及其带来的利益之外这一紧迫问题,就需要转变模式。因此,我们代表得不到充分服务的边缘化人群,制定了 "共促变革"(T4C)倡议,作为解决这一问题的独特的公私合作伙伴关系。T4C 计划所设计的综合方案由 Meharry 医学院创办的散居人口人类基因组学研究所负责管理,这些方案将改变教育和医疗保健的格局,并在未来几十年对全球黑人社区产生积极影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Diaspora Human Genomics Institute Launches the Together for Change Initiative: A Transformative, Historic Partnership to Ensure Health Equity in a Time of Unprecedented Technological Advancements.

Human subjects research and drug and device development currently base their findings largely on the genetic data of the non-Hispanic White population, excluding People of Color. This practice puts People of Color at a distinct and potentially deadly disadvantage in being treated for sickness, disability, and disease, as seen during the COVID-19 pandemic. Major disparities exist in all chronic health conditions, including cancer. Data show that less than 2% of genetic information being studied today originates from people of African ancestry. If genomic datasets do not adequately represent People of Color, new drugs and genetic therapies may not work as well as for people of European descent. Addressing the urgent concern that historically marginalized people may again be excluded from the next technological leap affecting human health and the benefits it will bring will requires a paradigm shift. Thus, on behalf of underserved and marginalized people, we developed the Together for CHANGE (T4C) initiative as a unique collaborative public-private partnership to address the concern. The comprehensive programs designed in the T4C initiative, governed by the Diaspora Human Genomics Institute founded by Meharry Medical College, will transform the landscape of education and health care and positively affect global Black communities for decades to come.

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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
154
期刊介绍: The journal has as its goal the dissemination of information on the health of, and health care for, low income and other medically underserved communities to health care practitioners, policy makers, and community leaders who are in a position to effect meaningful change. Issues dealt with include access to, quality of, and cost of health care.
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