阿尔茨海默病中的 Aβ 蛋白聚合：成核参数估计的优化控制。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-26 DOI:10.1016/j.jtbi.2024.111814

Ciuperca S. Ionel , Moncef Mahjoub , Tine Léon Matar

{"title":"阿尔茨海默病中的 Aβ 蛋白聚合：成核参数估计的优化控制。","authors":"Ciuperca S. Ionel , Moncef Mahjoub , Tine Léon Matar","doi":"10.1016/j.jtbi.2024.111814","DOIUrl":null,"url":null,"abstract":"<div><p>In this paper, we are interested in the modeling of Alzheimer’s disease from the angle of the amyloid cascade hypothesis, where the pathogenic agent is the A<span><math><mi>β</mi></math></span> protein in its oligomeric form. The formation dynamics of this pathogenic form is modeled by a Becker–Doring type model where APP (Amyloid Precursor Protein) protein, after cleavage by specific enzymes, forms monomeric A<span><math><mi>β</mi></math></span> proteins, which, by polymerization and/or nucleation, lead to the formation of oligomeric A<span><math><mi>β</mi></math></span>. We propose an optimal control problem to estimate the rate of nucleation which seems to be at the base of this amyloid cascade hypothesis and for which no (experimental) measurement exists for the moment.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aβ-protein polymerization in Alzheimer disease: Optimal control for nucleation parameter estimation\",\"authors\":\"Ciuperca S. Ionel , Moncef Mahjoub , Tine Léon Matar\",\"doi\":\"10.1016/j.jtbi.2024.111814\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this paper, we are interested in the modeling of Alzheimer’s disease from the angle of the amyloid cascade hypothesis, where the pathogenic agent is the A<span><math><mi>β</mi></math></span> protein in its oligomeric form. The formation dynamics of this pathogenic form is modeled by a Becker–Doring type model where APP (Amyloid Precursor Protein) protein, after cleavage by specific enzymes, forms monomeric A<span><math><mi>β</mi></math></span> proteins, which, by polymerization and/or nucleation, lead to the formation of oligomeric A<span><math><mi>β</mi></math></span>. We propose an optimal control problem to estimate the rate of nucleation which seems to be at the base of this amyloid cascade hypothesis and for which no (experimental) measurement exists for the moment.</p></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-04-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S002251932400095X\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002251932400095X","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

在本文中，我们从淀粉样蛋白级联假说的角度对阿尔茨海默病的建模感兴趣，其中致病因子是低聚物形式的 Aβ 蛋白。这种致病形式的形成动力学模型是 Becker-Doring 型模型，其中 APP（淀粉样前体蛋白）蛋白在被特定酶裂解后形成单体 Aβ 蛋白，单体 Aβ 蛋白通过聚合和/或成核形成低聚 Aβ。我们提出了一个优化控制问题，以估算成核率，这似乎是淀粉样蛋白级联假说的基础，但目前还没有（实验）测量数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Aβ-protein polymerization in Alzheimer disease: Optimal control for nucleation parameter estimation

In this paper, we are interested in the modeling of Alzheimer’s disease from the angle of the amyloid cascade hypothesis, where the pathogenic agent is the A $β$ protein in its oligomeric form. The formation dynamics of this pathogenic form is modeled by a Becker–Doring type model where APP (Amyloid Precursor Protein) protein, after cleavage by specific enzymes, forms monomeric A $β$ proteins, which, by polymerization and/or nucleation, lead to the formation of oligomeric A $β$ . We propose an optimal control problem to estimate the rate of nucleation which seems to be at the base of this amyloid cascade hypothesis and for which no (experimental) measurement exists for the moment.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.