{"title":"美国两个队列中基线膳食脂肪酸摄入量对脂蛋白（a）与死亡率之间关系的影响。","authors":"Nimai Patel, Chaitanya Chennareddy, Eric J Brandt","doi":"10.1177/20480040241247394","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Lipoprotein(a) (Lp(a)) is an established casual risk factor for atherosclerotic cardiovascular disease. It remains unknown whether dietary fat modifies the association of Lp(a) with cardiovascular death.</p><p><strong>Aim: </strong>To understand if dietary fat modifies the association between Lp(a) and cardiovascular death.</p><p><strong>Methods: </strong>We utilized the Atherosclerotic Risk in Communities (ARIC) study and National Health and Nutrition Examination Survey (NHANES) III cohorts and used multivariate cox proportional hazard modeling to test the association between Lp(a), dietary fats, and cardiovascular death.</p><p><strong>Results: </strong>The sample (<i>n</i> = 22,805) had average age 51.3 years and was mostly female (55.4%). Lp(a) ≥ 30 mg/dL was associated with CV death in both ARIC (1.36, <i>p</i> = 0.001) and NHANES (1.31, <i>p</i> = 0.03). In multivariate analysis, no categorical or individual fatty acids modified the association between Lp(a) and CV death.</p><p><strong>Conclusion: </strong>There was no evidence that baseline dietary fat intake modified the association between Lp(a) and CV death.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":"13 ","pages":"20480040241247394"},"PeriodicalIF":1.4000,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11008349/pdf/","citationCount":"0","resultStr":"{\"title\":\"The impact of baseline dietary fatty acid intake on the association between lipoprotein(a) and mortality in two US cohorts.\",\"authors\":\"Nimai Patel, Chaitanya Chennareddy, Eric J Brandt\",\"doi\":\"10.1177/20480040241247394\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Lipoprotein(a) (Lp(a)) is an established casual risk factor for atherosclerotic cardiovascular disease. It remains unknown whether dietary fat modifies the association of Lp(a) with cardiovascular death.</p><p><strong>Aim: </strong>To understand if dietary fat modifies the association between Lp(a) and cardiovascular death.</p><p><strong>Methods: </strong>We utilized the Atherosclerotic Risk in Communities (ARIC) study and National Health and Nutrition Examination Survey (NHANES) III cohorts and used multivariate cox proportional hazard modeling to test the association between Lp(a), dietary fats, and cardiovascular death.</p><p><strong>Results: </strong>The sample (<i>n</i> = 22,805) had average age 51.3 years and was mostly female (55.4%). Lp(a) ≥ 30 mg/dL was associated with CV death in both ARIC (1.36, <i>p</i> = 0.001) and NHANES (1.31, <i>p</i> = 0.03). In multivariate analysis, no categorical or individual fatty acids modified the association between Lp(a) and CV death.</p><p><strong>Conclusion: </strong>There was no evidence that baseline dietary fat intake modified the association between Lp(a) and CV death.</p>\",\"PeriodicalId\":30457,\"journal\":{\"name\":\"JRSM Cardiovascular Disease\",\"volume\":\"13 \",\"pages\":\"20480040241247394\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11008349/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JRSM Cardiovascular Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/20480040241247394\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JRSM Cardiovascular Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/20480040241247394","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
The impact of baseline dietary fatty acid intake on the association between lipoprotein(a) and mortality in two US cohorts.
Background: Lipoprotein(a) (Lp(a)) is an established casual risk factor for atherosclerotic cardiovascular disease. It remains unknown whether dietary fat modifies the association of Lp(a) with cardiovascular death.
Aim: To understand if dietary fat modifies the association between Lp(a) and cardiovascular death.
Methods: We utilized the Atherosclerotic Risk in Communities (ARIC) study and National Health and Nutrition Examination Survey (NHANES) III cohorts and used multivariate cox proportional hazard modeling to test the association between Lp(a), dietary fats, and cardiovascular death.
Results: The sample (n = 22,805) had average age 51.3 years and was mostly female (55.4%). Lp(a) ≥ 30 mg/dL was associated with CV death in both ARIC (1.36, p = 0.001) and NHANES (1.31, p = 0.03). In multivariate analysis, no categorical or individual fatty acids modified the association between Lp(a) and CV death.
Conclusion: There was no evidence that baseline dietary fat intake modified the association between Lp(a) and CV death.
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