二甲双胍作为丙型肝炎病毒感染及相关并发症的辅助治疗药物。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
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引用次数: 0

摘要

丙型肝炎病毒是导致肝炎、肝硬化和肝细胞癌的重要全球性病因。这些感染还可能导致肝外表现,包括胰岛素抵抗和 2 型糖尿病。这两种并发症可能会降低某些治疗这种感染的药物方案的持续病毒学应答(SVR)。二甲双胍具有重要的生化作用,可限制病毒在细胞培养物中的复制,并可改善对基于利巴韦林和干扰素的抗病毒药物治疗的反应。临床研究将使用干扰素、利巴韦林和二甲双胍的治疗方案与不使用二甲双胍的治疗方案进行了比较,结果表明,二甲双胍可增加病毒清除率,提高 SVR 率,并增加胰岛素敏感性。二甲双胍还能降低 SVR 患者发生肝细胞癌的频率。需要进行更大规模的治疗试验,以确定二甲双胍对使用新型抗病毒药物的糖尿病患者的短期和长期治疗效果。特别是,如果二甲双胍能降低肝硬化和肝细胞癌的发病率,这将大大降低与这种感染相关的发病率和死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metformin as adjuvant treatment in hepatitis C virus infections and associated complications

Hepatitis C virus is an important global cause of hepatitis and subsequently cirrhosis and hepatocellular carcinoma. These infections may also cause extrahepatic manifestations, including insulin resistance and type 2 diabetes mellitus. These two complications can potentially reduce sustained virologic responses (SVR) in some drug regimens for this infection. Metformin has important biochemical effects that can limit viral replication in cellular cultures and can improve the response to antiviral drug therapy based on ribavirin and interferon. Clinical studies comparing treatment regimens with interferon, ribavirin, metformin with these regimens without metformin have demonstrated that metformin increases viral clearance, establishes higher rates of SVRs, and increases insulin sensitivity. Metformin also reduces the frequency of hepatocellular carcinoma in patients who have had SVRs. Larger treatment trials are needed to determine metformin's short-term and long-term treatment effects in patients with diabetes using newer antiviral drugs. In particular, if metformin reduces the frequency of cirrhosis and hepatocellular carcinoma, this would significantly reduce the morbidity and mortality associated with this infection.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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