综述与糖尿病并发症：叙述性综述。

IF 2.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

American Journal of the Medical Sciences Pub Date : 2024-08-01 DOI:10.1016/j.amjms.2024.04.017

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引用次数: 0

摘要

Syndecan（SDC）是硫酸肝素蛋白多糖（HSPG）家族的成员。据报道，在糖尿病（DM）模型中，肾脏、视网膜和心肌中的 SDCs 水平降低，看来它在糖尿病并发症的病因中起了作用。在糖尿病模型中，肾脏、视网膜和心肌中的 SDCs 水平降低。SDCs 水平的降低可能在糖尿病患者白蛋白尿的形成过程中起着重要作用。一些研究提供了支持 SDCs 在 DM 中作用机制的证据。然而，SDCs 及其分子机制非常复杂，需要进一步阐明。本综述重点探讨 SDCs 参与糖尿病并发症发生和发展的分子机制，这可能有助于开发预防和治疗这些并发症的新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Syndecans and diabetic complications: A narrative review

Syndecan (SDC) is a member of the heparan sulfate proteoglycan (HSPG) family. It appears to play a role in the aetiology of diabetic complications, with decreased levels of SDCs being reported in the kidney, retina, and cardiac muscle in models of diabetes mellitus (DM). The reduced levels of SDCs may play an important role in the development of albuminuria in DM. Some studies have provided the evidence supporting the mechanisms underlying the role of SDCs in DM. However, SDCs and the molecular mechanisms involved are complex and need to be further elucidated. This review focuses on the underlying molecular mechanisms of SDCs that are involved in the development and progression of the complications of DM, which may help in developing new strategies to prevent and treat these complications.

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来源期刊

American Journal of the Medical Sciences 医学-医学：内科

CiteScore

4.40

自引率

0.00%

发文量

303

审稿时长

1.5 months

期刊介绍： The American Journal of The Medical Sciences (AJMS), founded in 1820, is the 2nd oldest medical journal in the United States. The AJMS is the official journal of the Southern Society for Clinical Investigation (SSCI). The SSCI is dedicated to the advancement of medical research and the exchange of knowledge, information and ideas. Its members are committed to mentoring future generations of medical investigators and promoting careers in academic medicine. The AJMS publishes, on a monthly basis, peer-reviewed articles in the field of internal medicine and its subspecialties, which include: Original clinical and basic science investigations Review articles Online Images in the Medical Sciences Special Features Include: Patient-Centered Focused Reviews History of Medicine The Science of Medical Education.