从共识声明到药片再到像素:注意缺陷/多动障碍治疗的新创新。

IF 1.5 4区 医学 Q2 PEDIATRICS
Raman Baweja, Stephen V Faraone, Ann C Childress, Margaret D Weiss, Sandra K Loo, Timothy E Wilens, James G Waxmonsky
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引用次数: 0

摘要

目的:本综述旨在介绍注意力缺陷/多动障碍(ADHD)治疗的最新创新和进展,包括国际共识声明、新药物配方、数字疗法和神经刺激设备。研究方法对过去五年中发表的相关文章进行了全面的文献检索,强调了这些进展的证据基础、疗效、安全性和实际意义。结果世界多动症联合会共识声明》提供了一个以全球科学证据为基础的最新诊断和治疗框架。目前有几种较新的多动症药物配方,包括一种非刺激剂(维洛沙嗪缓释剂)和第一种获准用于治疗多动症的透皮苯丙胺贴剂。这些选择具有一些独特的优势,可根据症状特征、生活方式、偏好和反应进行个性化治疗。数字工具为多动症患者提供了更多调整环境的手段,减少了障碍和对他人的依赖。此外,数字疗法提高了多动症治疗的可及性、可负担性、个性化和可行性,补充或增强了现有的干预措施。三叉神经刺激疗法是一种耐受性良好的非药物、基于设备的小儿多动症治疗方法,初步试验表明其效果可与非兴奋剂药物相媲美。结论:多动症治疗领域的这些创新代表了具有临床意义的新治疗方案和个性化治疗的机会。医护人员应将这些发展融入临床实践中,同时注意患者和家属的个人需求和偏好。未来的研究应评估这些创新疗法的长期疗效、成本效益和可接受性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
From Consensus Statement to Pills to Pixels: New Innovations in Attention-Deficit/Hyperactivity Disorder Care.

Objectives: This review aims to present recent innovations and advancements in attention-deficit/hyperactivity disorder (ADHD) care, encompassing international consensus statement, new medication formulations, digital therapeutics, and neurostimulation devices. Methods: A comprehensive literature search of relevant articles published in the past five years was conducted, emphasizing the evidence base, efficacy, safety, and practical implications of these advancements. Results: The World Federation of ADHD Consensus Statement offers an updated diagnostic and treatment framework rooted in global scientific evidence. There are several newer ADHD medication formulations, including a nonstimulant (Viloxazine extended release) and the first transdermal amphetamine patch approved to treat ADHD. These options offer some unique benefits to personalize treatment based on symptom profile, lifestyle, preferences, and response. Digital tools offer additional means to restructure environments for individuals with ADHD, reducing impairment and reliance on others. In addition, digital therapeutics enhance access, affordability, personalization, and feasibility of ADHD care, complementing or augmenting existing interventions. Trigeminal nerve stimulation emerges as a well-tolerated nonpharmacological, device-based treatment for pediatric ADHD, with initial trials indicating effect sizes comparable to nonstimulant medications. Conclusions: These innovations in ADHD care represent clinically significant new treatment options and opportunities for personalized care. Health care professionals should integrate these developments into clinical practice, mindful of individual patient and family needs and preferences. Future research should assess long-term outcomes, cost-effectiveness, and acceptability of these innovations.

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来源期刊
CiteScore
3.60
自引率
5.30%
发文量
61
审稿时长
>12 weeks
期刊介绍: Journal of Child and Adolescent Psychopharmacology (JCAP) is the premier peer-reviewed journal covering the clinical aspects of treating this patient population with psychotropic medications including side effects and interactions, standard doses, and research on new and existing medications. The Journal includes information on related areas of medical sciences such as advances in developmental pharmacokinetics, developmental neuroscience, metabolism, nutrition, molecular genetics, and more. Journal of Child and Adolescent Psychopharmacology coverage includes: New drugs and treatment strategies including the use of psycho-stimulants, selective serotonin reuptake inhibitors, mood stabilizers, and atypical antipsychotics New developments in the diagnosis and treatment of ADHD, anxiety disorders, schizophrenia, autism spectrum disorders, bipolar disorder, eating disorders, along with other disorders Reports of common and rare Treatment Emergent Adverse Events (TEAEs) including: hyperprolactinemia, galactorrhea, weight gain/loss, metabolic syndrome, dyslipidemia, switching phenomena, sudden death, and the potential increase of suicide. Outcomes research.
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