德国 HPV 疫苗接种对癌症发病率可能产生影响的初步证据--聚焦宫颈癌。

IF 6.5 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Paula Grieger, Nora Eisemann, Friederike Hammersen, Christiane Rudolph, Alexander Katalinic, Annika Waldmann
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引用次数: 0

摘要

背景:人乳头瘤病毒(HPV)感染是德国较常见的性传播疾病之一。德国于 2007 年开始接种 HPV 疫苗。在这项研究中,我们试图发现在疫苗接种后的前 11 年中,符合接种条件的 30 岁以下女性宫颈癌发病率的下降情况:我们通过德国癌症登记数据中心(ZfKD)从德国各联邦州(Bundesländer)的癌症登记处获得了 2004 年至 2018 年新诊断的 HPV 相关宫颈癌数据。通过对数线性连接点回归和年龄-时期-队列模型确定了浸润性和原位宫颈癌的发病趋势:结果:宫颈癌的发病率在过去几十年中一直呈上升趋势,但自 2010 年以来一直在下降,符合接种条件的各年龄组女性的发病率都有明显下降(例如,24 至 26 岁女性的发病率从 2010 年的每年每 10 万人 70.0 例降至 2018 年的 41.8 例)。1992 年出生的女性最先获得接种资格,其发病率比 1989 年出生的女性参照队列低 24%(相对风险为 0.76,95% 置信区间 [0.68; 0.86])。在疫苗接种更为普及的较晚出生队列中,发现了更大的影响:结论:HPV 疫苗接种 11 年后,在符合疫苗接种条件的出生组群中,宫颈癌的发病率在人群水平上有所下降。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Initial Evidence of a Possible Effect of HPV Vaccination on Cancer Incidence in Germany—Focus on Cervical Cancer.

Background: Infection with human papillomavirus (HPV) is one of the more common sexually transmitted diseases in Germany. Vaccination against HPV was introduced in Germany in 2007. In this study, we sought to detect a population-based decline in the incidence of cervical cancer in women under age 30 who were eligible for vaccination in the first 11 years after its introduction.

Methods: Data on new diagnoses of HPV-associated cervical cancer from 2004 to 2018 were obtained from the cancer registries of the German federal states (Bundesländer) through the German Center for Cancer Registry Data (ZfKD). Trends in the incidence of invasive and in situ cervical cancer were determined with log-linear joinpoint regression and age-period-cohort models.

Results: The incidence of cervical cancer, which had been rising in the previous decades, has been falling since 2010, with a marked decline among women in all age groups eligible for vaccination (e.g., from 70.0 to 41.8 cases per 100 000 persons per year from 2010 to 2018 in women aged 24 to 26). Women born in 1992 were the first to become eligible for vaccination and have a 24% lower incidence than the reference cohort of women born in 1989 (relative risk 0.76, 95% confidence interval [0.68; 0.86]). Larger effects were found in later birth cohorts, in which vaccination was more widespread.

Conclusion: Eleven years after the introduction of HPV vaccination, a drop in the incidence of cervical cancer was observable at the population level in the birth cohorts eligible for vaccination.

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来源期刊
Deutsches Arzteblatt international
Deutsches Arzteblatt international 医学-医学:内科
CiteScore
4.10
自引率
5.20%
发文量
306
审稿时长
4-8 weeks
期刊介绍: Deutsches Ärzteblatt International is a bilingual (German and English) weekly online journal that focuses on clinical medicine and public health. It serves as the official publication for both the German Medical Association and the National Association of Statutory Health Insurance Physicians. The journal is dedicated to publishing independent, peer-reviewed articles that cover a wide range of clinical medicine disciplines. It also features editorials and a dedicated section for scientific discussion, known as correspondence. The journal aims to provide valuable medical information to its international readership and offers insights into the German medical landscape. Since its launch in January 2008, Deutsches Ärzteblatt International has been recognized and included in several prestigious databases, which helps to ensure its content is accessible and credible to the global medical community. These databases include: Carelit CINAHL (Cumulative Index to Nursing and Allied Health Literature) Compendex DOAJ (Directory of Open Access Journals) EMBASE (Excerpta Medica database) EMNursing GEOBASE (Geoscience & Environmental Data) HINARI (Health InterNetwork Access to Research Initiative) Index Copernicus Medline (MEDLARS Online) Medpilot PsycINFO (Psychological Information Database) Science Citation Index Expanded Scopus By being indexed in these databases, Deutsches Ärzteblatt International's articles are made available to researchers, clinicians, and healthcare professionals worldwide, contributing to the global exchange of medical knowledge and research.
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