白内障手术后 Rho 相关激酶抑制剂滴眼液（Ripasudil）对角膜内皮细胞的保护作用：一项前瞻性比较研究

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-06-01 Epub Date: 2024-04-30 DOI:10.1007/s40123-024-00950-x

Majed Alkharashi, Mohammed M Abusayf, Wael Otaif, Abdullah Alkharashi

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引用次数: 0

摘要

导言白内障手术对角膜内皮细胞构成风险。本研究旨在评估Rho相关激酶抑制剂滴眼液（利帕苏地尔）在12个月内对白内障手术后角膜内皮细胞的保护作用：我们进行了一项前瞻性、非随机、非盲比对研究，将43名患者分为两组：利帕苏地尔组（22名患者，23只眼）和对照组（21名患者，21只眼）。所有患者均为3级核性白内障，均接受了顺利的超声乳化术和眼内人工晶体植入术。在瑞帕苏地尔组，每天滴用一滴盐酸瑞帕苏地尔水合物（Glanatec® 眼科溶液，0.4%），每天三次，持续 5 天。结果测量包括角膜中央厚度（CCT）和内皮细胞密度（ECD），分别在术前和术后12个月进行评估：结果：在利帕旭地尔组中，基线ECD中位数为2398个细胞/平方毫米（四分位距[IQR]410，2201-2611），术后12个月为2262个细胞/平方毫米（四分位距[IQR]298，2195-2493）。对照组的 ECD 中位数在基线时为 2503（IQR 390，2340-2730）个/mm2 细胞，术后 12 个月时为 2170（IQR 324，2049-2373）个/mm2 细胞。对照组的内皮细胞丢失率（ECL）为 12.8%，而瑞帕苏地尔组的内皮细胞丢失率（ECL）则明显降低至 4.5%（p = 0.001*）。CCT（p = 0.042）、年龄（p = 0.383）、性别（p = 0.944）和手术持续时间（p = 0.319）均非重要因素。两组患者均未观察到不良反应：结论：将利帕昔单抗纳入术后管理有助于维持角膜内皮细胞的完整性，减少白内障手术后细胞的丢失，从而降低眼内手术患者对内皮移植的需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Protective Effect of Rho-Associated Kinase Inhibitor Eye Drops (Ripasudil) on Corneal Endothelial Cells After Cataract Surgery: A Prospective Comparative Study.

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The Protective Effect of Rho-Associated Kinase Inhibitor Eye Drops (Ripasudil) on Corneal Endothelial Cells After Cataract Surgery: A Prospective Comparative Study.

Introduction: Cataract surgery poses a risk to corneal endothelial cells. This study aimed to assess the protective effect of rho-associated kinase inhibitor eye drop (ripasudil) on corneal endothelial cells after cataract surgery over 12 months.

Methods: We conducted a prospective, non-randomized, non-blinded comparative study including 43 patients divided into two groups: the ripasudil group (22 patients, 23 eyes) and the control group (21 patients, 21 eyes). All patients had grade 3 nuclear cataract and underwent uneventful phacoemulsification with intraocular lens implantation. In the ripasudil group, one drop of ripasudil hydrochloride hydrate (Glanatec® ophthalmic solution 0.4%) was administered three times a day for 5 days. Outcome measures included central corneal thickness (CCT) and endothelial cell density (ECD), which were evaluated preoperatively and 12 months postoperatively.

Results: In the ripasudil group, the median ECD was 2398 (interquartile range [IQR] 410, 2201-2611) cells/mm² at baseline and 2262 (IQR 298, 2195-2493) cells/mm² at 12 months postoperatively. In the control group, the median ECD was 2503 (IQR 390, 2340-2730) cells/mm² at baseline and 2170 (IQR 324, 2049-2373) cells/mm² at 12 months postoperatively. Endothelial cell loss (ECL) was 12.8% in the control group, significantly reduced to 4.5% in the ripasudil group (p = 0.001*). CCT (p = 0.042), age (p = 0.383), sex (p = 0.944), and duration of surgery (p = 0.319) were not significant factors. No adverse effects were observed in either of the groups.

Conclusions: Incorporating ripasudil into postoperative management could help maintain corneal endothelial cell integrity and reduce cell loss after cataract surgery, potentially decreasing the need for endothelial transplantation in patients who have undergone intraocular surgeries.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of ophthalmic therapies. Open Access All articles published by Ophthalmology and Therapy are open access. 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