相位角和阻抗比作为一组超重年轻女性结肠清洁方案后的元炎症生物标志物。

IF 2.3 4区 医学 Q3 BIOPHYSICS
L O Tapasco-Tapasco, C A Gonzalez-Correa, A Letourneur
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引用次数: 0

摘要

背景: 血液中的 C 反应蛋白(CRP)和生物电阻抗(EBI)变量相位角(PhA)和阻抗比(IR)已被提出作为超重/肥胖症元炎症的生物标志物。CRP 需要采集血液样本,而 PhA 和 IR 则是一种不到 2 分钟的非侵入性程序。在这项研究中,我们获得了这些变量的值和体脂率(PBFM),并在结肠清洁方案(CCP)前后进行了比较,目的是调节肠道微生物群,以及在结肠清洁方案结束后的 8 周内进行比较:超重组(OG)12 人,瘦身组(LG)8 人。超重组被分为两个分组(各 6 人):对照组(SCG)和实验组(SEG)。ESG 在第 2 周接受了为期 6 天的结肠清洁方案 (CCP),而 CSG 中的 5 名志愿者则在第 9 周接受了该方案:PBF(34.3/31.3%)、CRP(3.7/0.6 mg/dL)、PhA(6.9/7.5°)和 IR*10 (0.78/0.77)。这些变量之间的计算 R2 相关系数均高于 0.89)。首次在 SEG 中看到的有利变化在 CCP 8 周后仍然存在。结论:a)CCP 大幅降低了元炎症;b)EBIS 可用来测量治疗前后的元炎症;c)对于微生物群调节,CCP 可以很好地替代粪便微生物群移植等更激烈的治疗方法;d)通过 CCP 重建 eubiosis 可以有效辅助治疗超重的年轻成年超重女性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phase angle and impedance ratio as meta-inflammation biomarkers after a colon cleansing protocol in a group of overweight young women.

Objective. Blood C-reactive protein (CRP) and the electrical bioimpedance spectroscopy (EBIS) variables phase angle (PhA) and impedance ratio (IR) have been proposed as biomarkers of metainflammation in overweight/obesity. CRP involves taking blood samples, while PhA and IR imply a less-than-2-minute-non-invasive procedure. In this study, values for these variables and percent body fat mass (PBFM) were obtained and compared before and immediately after a colon cleansing protocol (CCP), aimed at modulating intestinal microbiota and reducing metainflammation, as dysbiosis and the latter are intrinsically related, as well as along a period of 8 weeks after it.Approach. 20 female volunteers (20.9-24.9 years old) participated: 12 in an overweight group (OG), and 8 in a lean group (LG). TheOGwas divided in two subgroups (n= 6, each): control (CSG) and experimental (ESG). TheESGunderwent a 6-day CCP at week 2, while 5 volunteers in theCSGunderwent it at week 9.Main results.Pre/post-CCP mean values for the variables in theOGwere: PBFM (34.3/31.3%), CRP (3.7/0.6 mg dl-1), PhA (6.9/7.5°) and IR*10 (0.78/0.77). CalculatedR2correlation factors among these variables are all above 0.89. The favourable changes first seen in theESGwere still present 8 weeks after the CCP.Significance.(a) the CCP drastically lowers meta-inflammation, (b) EBIS can be used to measure metainflammation, before and after treatment, (c) for microbiota modulation, CCP could be a good alternative to more drastic procedures like faecal microbiota transplantation; (d) reestablishing eubiosis by CCP could be an effective coadjutant in the treatment of overweight young adult women.

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来源期刊
Physiological measurement
Physiological measurement 生物-工程:生物医学
CiteScore
5.50
自引率
9.40%
发文量
124
审稿时长
3 months
期刊介绍: Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation. Papers are published on topics including: applied physiology in illness and health electrical bioimpedance, optical and acoustic measurement techniques advanced methods of time series and other data analysis biomedical and clinical engineering in-patient and ambulatory monitoring point-of-care technologies novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems. measurements in molecular, cellular and organ physiology and electrophysiology physiological modeling and simulation novel biomedical sensors, instruments, devices and systems measurement standards and guidelines.
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