L O Tapasco-Tapasco, C A Gonzalez-Correa, A Letourneur
{"title":"相位角和阻抗比作为一组超重年轻女性结肠清洁方案后的元炎症生物标志物。","authors":"L O Tapasco-Tapasco, C A Gonzalez-Correa, A Letourneur","doi":"10.1088/1361-6579/ad46df","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objective</i>. Blood C-reactive protein (CRP) and the electrical bioimpedance spectroscopy (EBIS) variables phase angle (PhA) and impedance ratio (IR) have been proposed as biomarkers of metainflammation in overweight/obesity. CRP involves taking blood samples, while PhA and IR imply a less-than-2-minute-non-invasive procedure. In this study, values for these variables and percent body fat mass (PBFM) were obtained and compared before and immediately after a colon cleansing protocol (CCP), aimed at modulating intestinal microbiota and reducing metainflammation, as dysbiosis and the latter are intrinsically related, as well as along a period of 8 weeks after it.<i>Approach</i>. 20 female volunteers (20.9-24.9 years old) participated: 12 in an overweight group (<b>OG</b>), and 8 in a lean group (<b>LG</b>). The<b>OG</b>was divided in two subgroups (<i>n</i>= 6, each): control (<b>CSG</b>) and experimental (<b>ESG</b>). The<b>ESG</b>underwent a 6-day CCP at week 2, while 5 volunteers in the<b>CSG</b>underwent it at week 9.<i>Main results.</i>Pre/post-CCP mean values for the variables in the<b>OG</b>were: PBFM (34.3/31.3%), CRP (3.7/0.6 mg dl<sup>-1</sup>), PhA (6.9/7.5°) and IR*10 (0.78/0.77). Calculated<i>R</i><sup>2</sup>correlation factors among these variables are all above 0.89. The favourable changes first seen in the<b>ESG</b>were still present 8 weeks after the CCP.<i>Significance.</i>(a) the CCP drastically lowers meta-inflammation, (b) EBIS can be used to measure metainflammation, before and after treatment, (c) for microbiota modulation, CCP could be a good alternative to more drastic procedures like faecal microbiota transplantation; (d) reestablishing eubiosis by CCP could be an effective coadjutant in the treatment of overweight young adult women.</p>","PeriodicalId":20047,"journal":{"name":"Physiological measurement","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Phase angle and impedance ratio as meta-inflammation biomarkers after a colon cleansing protocol in a group of overweight young women.\",\"authors\":\"L O Tapasco-Tapasco, C A Gonzalez-Correa, A Letourneur\",\"doi\":\"10.1088/1361-6579/ad46df\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Objective</i>. Blood C-reactive protein (CRP) and the electrical bioimpedance spectroscopy (EBIS) variables phase angle (PhA) and impedance ratio (IR) have been proposed as biomarkers of metainflammation in overweight/obesity. CRP involves taking blood samples, while PhA and IR imply a less-than-2-minute-non-invasive procedure. In this study, values for these variables and percent body fat mass (PBFM) were obtained and compared before and immediately after a colon cleansing protocol (CCP), aimed at modulating intestinal microbiota and reducing metainflammation, as dysbiosis and the latter are intrinsically related, as well as along a period of 8 weeks after it.<i>Approach</i>. 20 female volunteers (20.9-24.9 years old) participated: 12 in an overweight group (<b>OG</b>), and 8 in a lean group (<b>LG</b>). The<b>OG</b>was divided in two subgroups (<i>n</i>= 6, each): control (<b>CSG</b>) and experimental (<b>ESG</b>). The<b>ESG</b>underwent a 6-day CCP at week 2, while 5 volunteers in the<b>CSG</b>underwent it at week 9.<i>Main results.</i>Pre/post-CCP mean values for the variables in the<b>OG</b>were: PBFM (34.3/31.3%), CRP (3.7/0.6 mg dl<sup>-1</sup>), PhA (6.9/7.5°) and IR*10 (0.78/0.77). Calculated<i>R</i><sup>2</sup>correlation factors among these variables are all above 0.89. The favourable changes first seen in the<b>ESG</b>were still present 8 weeks after the CCP.<i>Significance.</i>(a) the CCP drastically lowers meta-inflammation, (b) EBIS can be used to measure metainflammation, before and after treatment, (c) for microbiota modulation, CCP could be a good alternative to more drastic procedures like faecal microbiota transplantation; (d) reestablishing eubiosis by CCP could be an effective coadjutant in the treatment of overweight young adult women.</p>\",\"PeriodicalId\":20047,\"journal\":{\"name\":\"Physiological measurement\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-05-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physiological measurement\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1088/1361-6579/ad46df\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiological measurement","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6579/ad46df","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOPHYSICS","Score":null,"Total":0}
Phase angle and impedance ratio as meta-inflammation biomarkers after a colon cleansing protocol in a group of overweight young women.
Objective. Blood C-reactive protein (CRP) and the electrical bioimpedance spectroscopy (EBIS) variables phase angle (PhA) and impedance ratio (IR) have been proposed as biomarkers of metainflammation in overweight/obesity. CRP involves taking blood samples, while PhA and IR imply a less-than-2-minute-non-invasive procedure. In this study, values for these variables and percent body fat mass (PBFM) were obtained and compared before and immediately after a colon cleansing protocol (CCP), aimed at modulating intestinal microbiota and reducing metainflammation, as dysbiosis and the latter are intrinsically related, as well as along a period of 8 weeks after it.Approach. 20 female volunteers (20.9-24.9 years old) participated: 12 in an overweight group (OG), and 8 in a lean group (LG). TheOGwas divided in two subgroups (n= 6, each): control (CSG) and experimental (ESG). TheESGunderwent a 6-day CCP at week 2, while 5 volunteers in theCSGunderwent it at week 9.Main results.Pre/post-CCP mean values for the variables in theOGwere: PBFM (34.3/31.3%), CRP (3.7/0.6 mg dl-1), PhA (6.9/7.5°) and IR*10 (0.78/0.77). CalculatedR2correlation factors among these variables are all above 0.89. The favourable changes first seen in theESGwere still present 8 weeks after the CCP.Significance.(a) the CCP drastically lowers meta-inflammation, (b) EBIS can be used to measure metainflammation, before and after treatment, (c) for microbiota modulation, CCP could be a good alternative to more drastic procedures like faecal microbiota transplantation; (d) reestablishing eubiosis by CCP could be an effective coadjutant in the treatment of overweight young adult women.
期刊介绍:
Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation.
Papers are published on topics including:
applied physiology in illness and health
electrical bioimpedance, optical and acoustic measurement techniques
advanced methods of time series and other data analysis
biomedical and clinical engineering
in-patient and ambulatory monitoring
point-of-care technologies
novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems.
measurements in molecular, cellular and organ physiology and electrophysiology
physiological modeling and simulation
novel biomedical sensors, instruments, devices and systems
measurement standards and guidelines.