揭开严重急性呼吸系统综合征冠状病毒 2 的复杂面纱:从眼科和全身的角度进行综合分析。

IF 1.9 4区 医学 Q2 OPHTHALMOLOGY
Piergiorgio Neri, Yanny Perez, Aniruddha Agarwal, Francesco Pichi
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引用次数: 0

摘要

这篇社论探讨了严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)大流行的深远影响,该病毒于 2019 年 12 月出现,并迅速演变成一场全球健康危机。尽管最初的重点是呼吸道症状,但该病毒对眼部造成了重大影响,促使人们重新评估眼睛在病毒传播、诊断和全身影响中的作用。在冠状病毒家族中,SARS-CoV-2 既新奇又熟悉,这种自相矛盾的特性是指导全球医疗应对措施的核心,包括迅速开发疫苗。这次大流行加强了对眼睛易受病毒感染的研究,提高了我们对病毒-宿主相互作用和病毒性疾病的全身影响的认识。社论深入探讨了 SARS-CoV-2 的病理生理学,强调了它引发自身炎症和自身免疫反应的可能性,并对眼部产生了重大影响。报告探讨了疫苗的快速开发和部署、相关的眼部副作用以及为减轻这些后果而正在进行的必要研究。随着世界卫生组织宣布 COVID-19 作为公共卫生紧急事件已经结束,人们已将重点转向了解该病毒的长期影响,包括其对眼部健康的影响。这项工作强调了跨学科合作在应对病毒感染的系统性影响方面的关键作用。它强调了眼科在更广泛的公共卫生背景下的重要性,并强调了在病毒流行后的世界里继续保持警惕、开展研究和进行调整的必要性。社论呼吁采取综合的医疗保健方法,强调从 SARS-CoV-2 大流行中吸取教训,为应对未来的健康挑战做好准备,并特别关注病毒学、免疫学和眼科学的交叉学科。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unraveling the Complexities of Severe Acute Respiratory Syndrome Coronavirus 2: A Comprehensive Ophthalmic and Systemic Perspective.

The editorial explores the profound implications of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic, which emerged in December 2019 and rapidly evolved into a global health crisis. Despite initial focus on respiratory symptoms, the virus revealed significant ocular implications, prompting a reevaluation of the eye's role in its transmission, diagnosis, and systemic effects. The paradoxical nature of SARS-CoV-2-simultaneously novel and familiar within the coronavirus family-has been central to guiding the global medical response, including the swift development of vaccines. The pandemic has intensified research into the eye's susceptibility to viral infections, enhancing our understanding of virus-host interactions and the systemic impacts of viral diseases. The editorial delves into the pathophysiology of SARS-CoV-2, highlighting its potential to trigger autoinflammatory and autoimmune reactions with significant ocular repercussions. It examines the rapid vaccine development and deployment, the associated ocular side effects, and the ongoing research necessary to mitigate these outcomes. As the World Health Organization declared the end of COVID-19 as a public health emergency, the focus has shifted toward understanding the virus's long-term implications, including its effects on ocular health. This work underscores the critical role of interdisciplinary collaboration in addressing the systemic impacts of viral infections. It emphasizes the importance of ophthalmology in the broader context of public health and highlights the need for continued vigilance, research, and adaptation in a postpandemic world. The editorial calls for an integrated approach to health care, emphasizing the lessons learned from the SARS-CoV-2 pandemic to prepare for future health challenges, with a particular focus on the intersection of virology, immunology, and ophthalmology.

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来源期刊
CiteScore
4.60
自引率
4.30%
发文量
72
审稿时长
1 months
期刊介绍: Journal of Ocular Pharmacology and Therapeutics is the only peer-reviewed journal that combines the fields of ophthalmology and pharmacology to enable optimal treatment and prevention of ocular diseases and disorders. The Journal delivers the latest discoveries in the pharmacokinetics and pharmacodynamics of therapeutics for the treatment of ophthalmic disorders. Journal of Ocular Pharmacology and Therapeutics coverage includes: Glaucoma Cataracts Retinal degeneration Ocular infection, trauma, and toxicology Ocular drug delivery and biotransformation Ocular pharmacotherapy/clinical trials Ocular inflammatory and immune disorders Gene and cell-based therapies Ocular metabolic disorders Ocular ischemia and blood flow Proliferative disorders of the eye Eyes on Drug Discovery - written by Gary D. Novack, PhD, featuring the latest updates on drug and device pipeline developments as well as policy/regulatory changes by the FDA.
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