[参与肝癌糖酵解调控的非编码 RNA 的研究进展]。

Q3 Medicine

生理学报 Pub Date : 2024-04-25

Xiao-Feng Hu, Qing Zhang, Mei-Lv Liang, Qing-Niao Zhou, Rui-Qiang Zhao, Zu-Kang Gong, Wen-Zhen Lin

{"title":"[参与肝癌糖酵解调控的非编码 RNA 的研究进展]。","authors":"Xiao-Feng Hu, Qing Zhang, Mei-Lv Liang, Qing-Niao Zhou, Rui-Qiang Zhao, Zu-Kang Gong, Wen-Zhen Lin","doi":"","DOIUrl":null,"url":null,"abstract":"Liver cancer is a common tumor of digestive system. Hepatocellular carcinoma (HCC) is a common type of liver cancer, which has a high degree of malignancy and ranks among the top causes of cancer-related death in the world. Metabolic reprogramming is considered to be an important marker of carcinogenesis. Glucose metabolism is one of the main ways for cells to produce energy. Glycolysis, as the basic reaction of glucose metabolism, plays an important role in cell metabolism. Therefore, the regulation of glycolysis is of great significance to the proliferation and evolution of tumors. More and more non-coding RNAs (ncRNA) have been proved to play an important role in the regulation of tumor glycolysis. This article reviews the role of ncRNA in the regulation of HCC glycolysis and its related mechanisms. At the same time, the prospect of targeted therapy for HCC based on the related mechanisms of glycolysis regulation is put forward.","PeriodicalId":7134,"journal":{"name":"生理学报","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma].\",\"authors\":\"Xiao-Feng Hu, Qing Zhang, Mei-Lv Liang, Qing-Niao Zhou, Rui-Qiang Zhao, Zu-Kang Gong, Wen-Zhen Lin\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Liver cancer is a common tumor of digestive system. Hepatocellular carcinoma (HCC) is a common type of liver cancer, which has a high degree of malignancy and ranks among the top causes of cancer-related death in the world. Metabolic reprogramming is considered to be an important marker of carcinogenesis. Glucose metabolism is one of the main ways for cells to produce energy. Glycolysis, as the basic reaction of glucose metabolism, plays an important role in cell metabolism. Therefore, the regulation of glycolysis is of great significance to the proliferation and evolution of tumors. More and more non-coding RNAs (ncRNA) have been proved to play an important role in the regulation of tumor glycolysis. This article reviews the role of ncRNA in the regulation of HCC glycolysis and its related mechanisms. At the same time, the prospect of targeted therapy for HCC based on the related mechanisms of glycolysis regulation is put forward.\",\"PeriodicalId\":7134,\"journal\":{\"name\":\"生理学报\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"生理学报\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"生理学报","FirstCategoryId":"1087","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

肝癌是一种常见的消化系统肿瘤。肝细胞癌（HCC）是一种常见的肝癌，恶性程度高，是世界上与癌症相关的死亡原因中最主要的一种。代谢重编程被认为是致癌的一个重要标志。葡萄糖代谢是细胞产生能量的主要途径之一。糖酵解作为葡萄糖代谢的基本反应，在细胞代谢中发挥着重要作用。因此，糖酵解的调控对肿瘤的增殖和进化具有重要意义。越来越多的非编码 RNA（ncRNA）被证实在肿瘤糖酵解的调控中发挥着重要作用。本文综述了 ncRNA 在 HCC 糖酵解调控中的作用及其相关机制。同时，基于糖酵解调控的相关机制，展望了HCC的靶向治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma].

Liver cancer is a common tumor of digestive system. Hepatocellular carcinoma (HCC) is a common type of liver cancer, which has a high degree of malignancy and ranks among the top causes of cancer-related death in the world. Metabolic reprogramming is considered to be an important marker of carcinogenesis. Glucose metabolism is one of the main ways for cells to produce energy. Glycolysis, as the basic reaction of glucose metabolism, plays an important role in cell metabolism. Therefore, the regulation of glycolysis is of great significance to the proliferation and evolution of tumors. More and more non-coding RNAs (ncRNA) have been proved to play an important role in the regulation of tumor glycolysis. This article reviews the role of ncRNA in the regulation of HCC glycolysis and its related mechanisms. At the same time, the prospect of targeted therapy for HCC based on the related mechanisms of glycolysis regulation is put forward.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.