关于鸢尾素对阿尔茨海默病患者认知功能障碍的调控机制以及鸢尾素在相关疾病中的干预作用的研究进展。

Q3 Medicine
生理学报 Pub Date : 2024-04-25
Tian Lan, Zong-Cheng Guo, Hao-Ran Gu, Lu Qin, En-Peng He
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引用次数: 0

摘要

鸢尾素是一种在运动过程中产生的多肽,据信在调节体内能量水平方面发挥着作用。此外,鸢尾素还能穿过血脑屏障,参与中枢神经系统内的各种病理生理过程。越来越多的研究发现,鸢尾素是神经退行性疾病的重要治疗靶点,这表明鸢尾素与认知障碍的发展之间存在密切联系。在本文中,我们简要回顾了不同类型的运动对鸢尾素分泌的影响,以及鸢尾素干预各种疾病(包括代谢性疾病、肾损伤和抑郁症)的机制。随后,我们深入探讨了鸢尾素在调节阿尔茨海默病患者(AD)认知功能障碍方面的作用,重点关注神经炎症、线粒体功能障碍和蛋白质错误折叠这三个关键领域的最新进展。最后,我们提出了三个假设:(1)运动诱导的纤连蛋白Ⅲ型结构域含蛋白5(FNDC5)刺激和随后的鸢尾素裂解可能与能量代谢中的应激反应有关;(2)鸢尾素作为一种肌动素,可能在线粒体修复机制中发挥作用,从而改善阿尔茨海默病患者的认知功能障碍;(3)鸢尾素是一种维持能量平衡的平衡因子,与机体内环境的动态稳定性密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research progress on the regulatory mechanisms of Irisin on cognitive dysfunction in patients with Alzheimer's disease and the interventional role of Irisin in associated diseases.

Irisin, a peptide produced during exercise, is believed to play a role in regulating energy levels within the body. Moreover, Irisin has the ability to traverse the blood-brain barrier and engage in various pathophysiological processes within the central nervous system. An increasing body of research identifies Irisin as a significant therapeutic target for neurodegenerative diseases, indicating a strong link between Irisin and the development of cognitive impairments. In this paper, we present a concise review of effects of different types of exercise on Irisin production, and the mechanisms underlying the Irisin's intervention in various diseases including metabolic diseases, kidney injury and depression. Following this, we delve into an in-depth exploration of its role in modulating cognitive dysfunction among patients with Alzheimer's disease (AD), focusing on recent advancements in three critical areas: neuroinflammation, mitochondrial dysfunction, and protein misfolding. Finally, we put forth 3 hypotheses: (1) exercise-induced fibronectin type III domain containing protein 5 (FNDC5) stimulation and subsequent Irisin cleavage may be associated with the stress response in energy metabolism; (2) Irisin, as a myokine, likely plays a role in mitochondrial repair mechanisms to ameliorate cognitive impairment in AD patients; (3) Irisin is a homeostatic factor that maintains energy homeostasis and is closely related to the dynamic stability of the body's internal environment.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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