前列腺素 E2 及其受体在慢性肝病中的作用。

Q3 Medicine
生理学报 Pub Date : 2024-04-25
Zhi-Qiang Lin, Yao Yao, Yu-Fei Zhang, Xiao-Yan Zhang, You-Fei Guan
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引用次数: 0

摘要

慢性肝病(CLD)是全球主要的健康负担,其发病率和死亡率不断上升。虽然许多疾病都可导致慢性肝病,进而导致肝硬化和肝细胞癌,但病毒性肝炎、药物性肝损伤、酒精性肝病和非酒精性脂肪肝是最常见的罪魁祸首。肝脏中产生的前列腺素 E2(PGE2)是一种重要的脂质介质,来源于ω-6 多不饱和脂肪酸--花生四烯酸,在肝脏稳态中发挥着关键作用。PGE2 的生理效应通过四类 E 型前列腺素(EP)受体(即 EP1、EP2、EP3 和 EP4)介导。近年来,越来越多的研究阐明了 PGE2 和 EP 受体在调节肝功能和 CLD 发病机制中的作用,从而产生了新的潜在临床影响。在这篇综述中,我们概述了 PGE2 的生物合成和调控,并讨论了其合成酶和受体在维持正常肝功能以及 CLD 的发生和发展中的作用。我们还讨论了 PGE2-EP 受体系统在治疗各种病因引起的慢性肝病中的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of prostaglandin E2 and its receptors in chronic liver disease.

Chronic liver disease (CLD) is a major global health burden in terms of growing morbidity and mortality. Although many conditions can cause CLD, leading to cirrhosis and hepatocellular carcinoma (HCC), viral hepatitis, drug-induced liver injury (DILI), alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the most common culprits. Prostaglandin E2 (PGE2), produced in the liver, is an important lipid mediator derived from the ω-6 polyunsaturated fatty acid, arachidonic acid, and plays a critical role in hepatic homeostasis. The physiological effects of PGE2 are mediated through four classes of E-type prostaglandin (EP) receptors, namely EP1, EP2, EP3 and EP4. In recent years, an increasing number of studies has been done to clarify the effects of PGE2 and EP receptors in regulating liver function and the pathogenesis of CLD to create a new potential clinical impact. In this review, we overview the biosynthesis and regulation of PGE2 and discuss the role of its synthesizing enzymes and receptors in the maintenance of normal liver function and the development and progress of CLD. We also discuss the potential of the PGE2-EP receptors system in treating CLD with various etiologies.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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