[迟发性肌肉酸痛的神经营养素相关机制:研究进展与展望]。

Q3 Medicine
生理学报 Pub Date : 2024-04-25
Yun-Xiao Liu, Jing Lei, Hao-Jun You
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引用次数: 0

摘要

延迟性肌肉酸痛(DOMS)是一种常见现象,发生在运动强度突然增加或不熟悉的运动之后,严重影响运动员和健身者的运动表现和效果。DOMS 的特点是异动和痛觉亢进,其机制尚不清楚。最近的研究报告称,神经生长因子(NGF)和胶质细胞衍生神经营养因子(GDNF)等神经营养因子参与了 DOMS 的发生和维持。本文综述了与 NGF 和 GDNF 参与 DOMS 相关的信号通路的研究进展,希望能对 DOMS 中异痛症和痛觉减退的机制以及潜在的靶向治疗提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Neurotrophin-associated mechanisms of delayed-onset muscle soreness: research progress and perspective].

Delayed-onset muscle soreness (DOMS) is a common phenomenon that occurs following a sudden increase in exercise intensity or unfamiliar exercise, significantly affecting athletic performance and efficacy in athletes and fitness individuals. DOMS is characterized by allodynia and hyperalgesia, and their mechanisms remain unclear. Recent studies have reported that neurotrophic factors, such as nerve growth factor (NGF) and glial cell derived neurotrophic factor (GDNF), are involved in the development and maintenance of DOMS. This article provides a review of the research progress on the signaling pathways related to the involvement of NGF and GDNF in DOMS, hoping to provide novel insights into the mechanisms underlying allodynia and hyperalgesia in DOMS, as well as potential targeted treatment.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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