内分泌治疗抗药性中癌细胞休眠和觉醒的表观遗传学控制

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2024-05-01 DOI:10.1158/2159-8290.CD-24-0282

Arnau Llinas-Bertran, Meritxell Bellet-Ezquerra, Jose A Seoane

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引用次数: 0

摘要

摘要Rosano、Sofyali、Dhiman及其同事的研究表明，在内分泌治疗（ET）诱导的雌激素受体阳性（ER+）乳腺癌休眠及其苏醒过程中，会发生与表观遗传相关的变化。以这些表观遗传学变化为靶点，可以阻止癌细胞进入休眠期，减少顽固癌细胞数量，增强 ET 在体外的细胞毒性作用。参见 Rosano 等人的相关文章，第 866 页（9）。

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Epigenetic Control of Cancer Cell Dormancy and Awakening in Endocrine Therapy Resistance.

Summary: Rosano, Sofyali, Dhiman, and colleagues show that epigenetic-related changes occur in endocrine therapy (ET)-induced dormancy in estrogen receptor positive (ER+) breast cancer, as well as in its reawakening. Targeting these epigenetic changes blocks the entrance to dormancy and reduces the persister cancer cell population, enhancing the cytotoxic effects of ET in vitro. See related article by Rosano et al., p. 866 (9).

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.