将 3D ED/MicroED 工作流程应用于下一个前沿领域。

IF 0.7 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Acta Crystallographica Section C Structural Chemistry Pub Date : 2024-06-01 Epub Date: 2024-05-07 DOI:10.1107/S2053229624004078

Mahira Aragon, Sarah E J Bowman, Chun Hsing Chen, M Jason de la Cruz, Daniel A Decato, Edward T Eng, Kristen M Flatt, Sahil Gulati, Yuchen Li, Charles J Lomba, Brandon Mercado, Jessalyn Miller, Lukáš Palatinus, William J Rice, David Waterman, Christina M Zimanyi

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引用次数: 0

摘要

我们报告了微晶电子衍射（3D ED/MicroED）的最新进展，这些进展是在纽约结构生物学中心（New York Structural Biology Center）的国家低温电子显微镜访问和培训中心（National Center for CryoEM Access and Training）举办的研讨会上讨论的。本快照介绍了该领域各方面的前沿发展，并指出了继续取得进展的潜在途径。主要章节讨论了仪器的使用、小分子和生物大分子的研究应用、数据采集硬件和软件、数据缩减软件以及报告和验证。3D ED/MicroED 仍处于被结构科学界广泛采用的早期阶段，有大量的扩展、增长和创新机会。

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Applying 3D ED/MicroED workflows toward the next frontiers.

We report on the latest advancements in Microcrystal Electron Diffraction (3D ED/MicroED), as discussed during a symposium at the National Center for CryoEM Access and Training housed at the New York Structural Biology Center. This snapshot describes cutting-edge developments in various facets of the field and identifies potential avenues for continued progress. Key sections discuss instrumentation access, research applications for small molecules and biomacromolecules, data collection hardware and software, data reduction software, and finally reporting and validation. 3D ED/MicroED is still early in its wide adoption by the structural science community with ample opportunities for expansion, growth, and innovation.

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来源期刊

Acta Crystallographica Section C Structural Chemistry CHEMISTRY, MULTIDISCIPLINARYCRYSTALLOGRAPH-CRYSTALLOGRAPHY

CiteScore

1.60

自引率

12.50%

发文量

148

期刊介绍： Acta Crystallographica Section C: Structural Chemistry is continuing its transition to a journal that publishes exciting science with structural content, in particular, important results relating to the chemical sciences. Section C is the journal of choice for the rapid publication of articles that highlight interesting research facilitated by the determination, calculation or analysis of structures of any type, other than macromolecular structures. Articles that emphasize the science and the outcomes that were enabled by the study are particularly welcomed. Authors are encouraged to include mainstream science in their papers, thereby producing manuscripts that are substantial scientific well-rounded contributions that appeal to a broad community of readers and increase the profile of the authors.