母婴体内的巨泌乳素:其来源是什么?

IF 3.8 2区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Norito Nishiyama, Naoki Hattori, Kohozo Aisaka, Masayuki Ishihara, Takanori Saito
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引用次数: 0

摘要

目的 巨泌乳素血症是导致高泌乳素血症的主要原因之一。本研究旨在阐明巨泌乳素(macro-PRL)的来源。方法 我们检测了 826 名孕妇血清中的巨泌乳素及其分娩时婴儿脐带中的巨泌乳素。通过聚乙二醇(PEG)沉淀法、凝胶过滤色谱法(GFC)和蛋白G(PG)吸收法对巨PRL进行了评估。结果 我们在 826 名孕妇中的 16 名(1.94%)和 14 名婴儿中检测到了巨PRL,这可能表明巨PRL有遗传性。然而,婴儿的巨PRL比率与母亲的比率呈正相关(GFC的r=0.72,p<0.001;PG的r=0.77,p<0.001),这表明免疫球蛋白(Ig)G型抗PRL自身抗体可能会通过胎盘主动转移给婴儿,并通过与婴儿的PRL结合形成巨PRL,或PRL-IgG复合物可能会通过胎盘。有两例只有母亲出现大PRL,这表明母亲体内的自身抗体没有通过胎盘,如IgA、与其他蛋白结合的PRL或PRL聚集体。没有发现只有婴儿有巨PRL而母亲没有的病例,这表明巨PRL可能不是由非遗传性先天性原因引起的。结论 育龄妇女的巨PRL可能主要是IgG型抗PRL自身抗体结合的PRL。婴儿体内的巨PRL可能是IgG型抗PRL自身抗体或PRL-IgG复合物从母亲体内经胎盘转移到婴儿体内。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Macroprolactin in mothers and their babies: what is its origin?
Objectives Macroprolactinemia is one of the major causes of hyperprolactinemia. The aim of this study was to clarify the origin of macroprolactin (macro-PRL). Methods We examined macro-PRL in the sera of 826 pregnant women and in those of their babies’ umbilical cords at delivery. Macro-PRL was evaluated by precipitation with polyethylene glycol (PEG), gel filtration chromatography (GFC), and absorption with protein G (PG). Results We detected macro-PRL in 16 out of the 826 pregnant women (1.94 %) and in 14 of their babies, which may indicate the possibility of hereditary origin of macro-PRL. However, the macro-PRL ratios of the babies correlated positively with those of their mothers (r=0.72 for GFC, p<0.001 and r=0.77 for PG, p<0.001), suggesting that the immunoglobulin (Ig)G-type anti-PRL autoantibodies might be actively transferred to babies via the placenta and form macro-PRL by binding to their babies’ PRL or PRL-IgG complexes may possibly pass through the placenta. There were two cases in which only mothers had macro-PRL, indicating that the mothers had autoantibodies that did not pass through the placenta, such as IgA, PRL bound to the other proteins or PRL aggregates. No cases were found in which only the babies had macro-PRL and their mothers did not, suggesting that macro-PRL might not arise by non-hereditary congenital causes. Conclusions Macro-PRL in women of reproductive age might be mostly IgG-type anti-PRL autoantibody-bound PRL. The likely origin of macro-PRL in babies is the transplacental transfer of IgG-type anti-PRL autoantibodies or PRL-IgG complexes from the mothers to their babies.
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来源期刊
Clinical chemistry and laboratory medicine
Clinical chemistry and laboratory medicine 医学-医学实验技术
CiteScore
11.30
自引率
16.20%
发文量
306
审稿时长
3 months
期刊介绍: Clinical Chemistry and Laboratory Medicine (CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor over 3. CCLM is issued monthly, and it is published in print and electronically. CCLM is the official journal of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) and publishes regularly EFLM recommendations and news. CCLM is the official journal of the National Societies from Austria (ÖGLMKC); Belgium (RBSLM); Germany (DGKL); Hungary (MLDT); Ireland (ACBI); Italy (SIBioC); Portugal (SPML); and Slovenia (SZKK); and it is affiliated to AACB (Australia) and SFBC (France). Topics: - clinical biochemistry - clinical genomics and molecular biology - clinical haematology and coagulation - clinical immunology and autoimmunity - clinical microbiology - drug monitoring and analysis - evaluation of diagnostic biomarkers - disease-oriented topics (cardiovascular disease, cancer diagnostics, diabetes) - new reagents, instrumentation and technologies - new methodologies - reference materials and methods - reference values and decision limits - quality and safety in laboratory medicine - translational laboratory medicine - clinical metrology Follow @cclm_degruyter on Twitter!
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