血液透析患者下半身骨折的死亡率高、预后差

IF 1.5 4区医学 Q3 HEMATOLOGY

Therapeutic Apheresis and Dialysis Pub Date : 2024-05-02 DOI:10.1111/1744-9987.14139

Kazuhiko Yoshikawa, Takuya Kishi, Ayako Takamori, Akira Kitajima, Taku Goto, Shiki Nakayama, Kohei Yamanouchi, Kuniyasu Takagi, Yoshitaka Hirooka, Kazuma Fujimoto, Naoya Nagata, Ouya Nagata, Fumihiro Kuroki, Nobuyoshi Fukuda, Yuichiro Akiyoshi, Takuaki Yamamoto

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引用次数: 0

摘要

导读] 本研究旨在探讨维持性血液透析过程中发生的下体骨折与预后之间的关系。方法本研究纳入了截至2017年12月我院透析中心的151例血液透析患者，从病历中系统收集数据，为期5年，至2022年12月结束。结果151例血液透析患者中有14例患者发生下体骨折，每100人年中有3.0例。下半身骨折组的男性比例明显低于无下半身骨折组，年龄也明显高于无下半身骨折组。下半身骨折组患者参加本研究前的血液透析时间明显短于无下半身骨折组。下半身骨折组的血清白蛋白明显低于无下半身骨折组，碱性磷酸酶明显高于无下半身骨折组。下体骨骨折组的死亡率（85.7%）明显高于无下体骨骨折组（28.5%）（P = 0.01）。死亡率的 Kaplan-Meier 生存曲线显示，与无下颌骨骨折组相比，下颌骨骨折组预后较差。结论血液透析患者下体骨骨折死亡率高，预后差。

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Lower body bone fractures have high mortality rates and poor prognosis in the patients with hemodialysis

IntroductionThe objective of the current study was to investigate the association between lower body bone fractures occurring during maintenance hemodialysis and prognosis.MethodsThis study included 151 hemodialysis patients at the dialysis center of our hospital as of December 2017, and data were systematically gathered from medical records over a period of 5 years, concluding in December 2022.ResultsFourteen patients, 3.0 per 100 person‐years, in 151 hemodialysis patients suffered from lower body bone fractures. The ratio of males was significantly lower, and age was significantly higher in the lower body bone fracture group than in the no lower body bone fracture group. Duration of hemodialysis prior to entry into this study was significantly shorter in the lower body bone fracture group than in the no lower body bone fracture group. Serum albumin was significantly lower and alkaline phosphatase was significantly higher in the lower body bone fracture group than in the no lower body bone fracture group. Mortality rate was significantly higher in the lower body bone fracture group (85.7%) compared to no lower body bone fracture group (28.5%) (p = 0.01). Kaplan–Meier survival curves for mortality showed that lower body bone fracture group had poor prognosis compared to no lower body bone fracture group. Multivariable‐adjusted odds ratio for mortality were significantly higher for cases with lower body bone fractures.ConclusionLower body bone fractures have high mortality rates and poor prognosis in the patients with hemodialysis.

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.