配体促进的钯催化β-C(sp3)-H 乙酮芳基化反应（以乙酰基酰肼作为瞬时指导基团

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC

Synlett Pub Date : 2024-04-29 DOI:10.1055/a-2310-0880

Kai Jia, Junjie Wang, Xuan Wang, Chao Jiang

引用次数: 0

摘要

通过使用乙酰肼作为瞬时指导基团，开发了一种钯催化的脂肪族酮的 β-C(sp3)-H 芳基化反应。该反应通过一个不太有利的[5,5]-双环帕拉代环中间体进行，并由吡啶配体促进。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ligand-Promoted Palladium-Catalyzed β-C(sp3)–H Arylation of Ketones Using Acetohydrazide as a Transient Directing Group

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Ligand-Promoted Palladium-Catalyzed β-C(sp3)–H Arylation of Ketones Using Acetohydrazide as a Transient Directing Group

A palladium-catalyzed β-C(sp³)–H arylation of aliphatic ketones by using acetohydrazide as a transient directing group has been developed. The reaction proceeds through a less-favored [5,5]-bicyclic palladacycle intermediate and is promoted by a pyridine ligand.

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.