刺猬信号通路在多能间质干细胞分化中的作用

IF 3.2 4区 医学 Q3 CELL & TISSUE ENGINEERING
Mengyu Wu, Junwei Mi, Guo-xin Qu, Shu Zhang, Yi Jian, Chu Gao, Qingli Cai, Jing Liu, Jianxin Jiang, Hong Huang
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引用次数: 0

摘要

多能间充质干细胞(MSCs)具有较高的自我更新和多系分化潜能,且免疫原性低,因此在再生医学领域备受关注,临床应用前景广阔。间充质干细胞起源于中胚层,不仅能分化成成骨细胞、软骨细胞、脂肪细胞和肌肉细胞,还能分化成胚胎各层的外胚层和内胚层细胞系。要设计用于替代受损组织的细胞疗法,就必须了解对间叶干细胞分化有重大影响的信号通路,因为这将有助于整合信号输入以启动特定的细胞系。刺猬(Hh)信号在胚胎各种组织和器官的发育过程中起着至关重要的作用。作为一种形态发生因子,Hh 不仅能调节组织祖细胞和干细胞的存活和增殖,还是间充质干细胞分化的关键调节因子,涉及间充质干细胞的三系分化和跨胚层分化。本综述总结了 Hh 信号通路在间充质干细胞向中胚层、内胚层和外胚层细胞分化过程中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Hedgehog Signaling Pathways in Multipotent Mesenchymal Stem Cells Differentiation
Multipotent mesenchymal stem cells (MSCs) have high self-renewal and multi-lineage differentiation potentials and low immunogenicity, so they have attracted much attention in the field of regenerative medicine and have a promising clinical application. MSCs originate from the mesoderm and can differentiate not only into osteoblasts, cartilage, adipocytes, and muscle cells but also into ectodermal and endodermal cell lineages across embryonic layers. To design cell therapy for replacement of damaged tissues, it is essential to understand the signaling pathways, which have a major impact on MSC differentiation, as this will help to integrate the signaling inputs to initiate a specific lineage. Hedgehog (Hh) signaling plays a vital role in the development of various tissues and organs in the embryo. As a morphogen, Hh not only regulates the survival and proliferation of tissue progenitor and stem populations but also is a critical moderator of MSC differentiation, involving tri-lineage and across embryonic layer differentiation of MSCs. This review summarizes the role of Hh signaling pathway in the differentiation of MSCs to mesodermal, endodermal, and ectodermal cells.
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来源期刊
Cell Transplantation
Cell Transplantation 生物-细胞与组织工程
CiteScore
6.00
自引率
3.00%
发文量
97
审稿时长
6 months
期刊介绍: Cell Transplantation, The Regenerative Medicine Journal is an open access, peer reviewed journal that is published 12 times annually. Cell Transplantation is a multi-disciplinary forum for publication of articles on cell transplantation and its applications to human diseases. Articles focus on a myriad of topics including the physiological, medical, pre-clinical, tissue engineering, stem cell, and device-oriented aspects of the nervous, endocrine, cardiovascular, and endothelial systems, as well as genetically engineered cells. Cell Transplantation also reports on relevant technological advances, clinical studies, and regulatory considerations related to the implantation of cells into the body in order to provide complete coverage of the field.
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