小儿移植中与爱泼斯坦-巴氏病毒相关的移植后淋巴组织增生性疾病：美国一项前瞻性多中心研究

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-29 DOI:10.1111/petr.14763

Tetsuya Tajima, Olivia M. Martinez, Daniel Bernstein, Scott D. Boyd, Dita Gratzinger, Grant Lum, Kazunari Sasaki, Brent Tan, Clare J. Twist, Kenneth Weinberg, Brian Armstrong, Dev M. Desai, George V. Mazariegos, Clifford Chin, Thomas M. Fishbein, Akin Tekin, Robert S. Venick, Sheri M. Krams, Carlos O. Esquivel

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引用次数: 0

摘要

背景与爱泼斯坦-巴氏病毒（EBV）相关的移植后淋巴组织增生性疾病（PTLD）是儿童移植后最常见的恶性肿瘤；然而，早期检测困难可能会使预后恶化。其中872名儿童在2014年至2019年期间在美国的7个中心接受了肝脏、心脏、肾脏、肠道或多脏器移植（NCT02182986）。活检共发现34例小儿EBV+ PTLD（3.9%）。变量包括性别、年龄、种族、民族、移植器官、EBV病毒载量、移植前EBV血清学、免疫抑制、对化疗和利妥昔单抗的反应以及组织病理学诊断。结果单变量/多变量竞争风险分析显示，EBV血清学阳性供体和EBV未感染受体（D+R-）组合是PTLD发生（亚危险比：2.79 [1.34-5.78]，p = .006）和EBV DNA血症（2.65 [1.72-4.09]，p <.001）的重要风险因素。D+R-患者与单形/多形PTLD的相关性明显高于其他组合（p = .02）。单形/多形 PTLD 患者（n = 21）的 EBV DNA 血症明显多于非 PTLD 患者（p <.001），而且在移植后 6 个月内，PTLD 的临床表现早于增生患者（p <.001）。结论D+R-是PTLD和EBV DNA血症的危险因素，与单形/多形PTLD的发病率有关。移植后6个月内加强EBV病毒载量随访，尤其是对D+R-患者和/或移植时年龄≥5岁的非肝移植受者进行随访，有助于在儿科移植早期发现单形/多形性PTLD。

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Epstein–Barr virus‐associated post‐transplant lymphoproliferative disorders in pediatric transplantation: A prospective multicenter study in the United States

BackgroundEpstein–Barr virus (EBV)‐associated post‐transplant lymphoproliferative disorders (PTLD) is the most common malignancy in children after transplant; however, difficulties for early detection may worsen the prognosis.MethodsThe prospective, multicenter, study enrolled 944 children (≤21 years of age). Of these, 872 received liver, heart, kidney, intestinal, or multivisceral transplants in seven US centers between 2014 and 2019 (NCT02182986). In total, 34 pediatric EBV+ PTLD (3.9%) were identified by biopsy. Variables included sex, age, race, ethnicity, transplanted organ, EBV viral load, pre‐transplant EBV serology, immunosuppression, response to chemotherapy and rituximab, and histopathological diagnosis.ResultsThe uni−/multivariable competing risk analyses revealed the combination of EBV‐seropositive donor and EBV‐naïve recipient (D+R−) was a significant risk factor for PTLD development (sub‐hazard ratio: 2.79 [1.34–5.78], p = .006) and EBV DNAemia (2.65 [1.72–4.09], p < .001). Patients with D+R− were significantly more associated with monomorphic/polymorphic PTLD than those with the other combinations (p = .02). Patients with monomorphic/polymorphic PTLD (n = 21) had significantly more EBV DNAemia than non‐PTLD patients (p < .001) and an earlier clinical presentation of PTLD than patients with hyperplasias (p < .001), within 6‐month post‐transplant. Among non‐liver transplant recipients, monomorphic/polymorphic PTLD were significantly more frequent than hyperplasias in patients ≥5 years of age at transplant (p = .01).ConclusionsD+R− is a risk factor for PTLD and EBV DNAemia and associated with the incidence of monomorphic/polymorphic PTLD. Intensive follow‐up of EBV viral load within 6‐month post‐transplant, especially for patients with D+R− and/or non‐liver transplant recipients ≥5 years of age at transplant, may help detect monomorphic/polymorphic PTLD early in pediatric transplant.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.