以单细胞分辨率观察早期人类胎盘对病原体的急性反应

IF 9 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Regina Hoo, Elias R. Ruiz-Morales, Iva Kelava, Mukul Rawat, Cecilia Icoresi Mazzeo, Elizabeth Tuck, Carmen Sancho-Serra, Sara Chelaghma, Alexander V. Predeus, Simon Murray, David Fernandez-Antoran, Ross F. Waller, Damiana Álvarez-Errico, Marcus C.S. Lee, Roser Vento-Tormo
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引用次数: 0

摘要

胎盘是母体和胎儿之间的一道选择性屏障,为母体和胎儿提供营养和免受感染的保护。然而,某些病原体会附着在胎盘上,甚至穿过胎盘,引起妊娠并发症,对胎儿的健康造成潜在的终生影响。在这里,我们在单细胞水平上分析了胎盘对三种与宫内并发症有关的病原体--恶性疟原虫、单核细胞增生李斯特菌和弓形虫的反应。我们发现,在接触病原体后,所有胎盘细胞系都会引发炎症反应,从而可能损害胎盘功能。此外,我们还描述了被称为霍夫鲍尔细胞(HBCs)的胎儿巨噬细胞对每种病原体的反应,并提出它们可能是弓形虫的栖息地。最后,我们揭示了恶性疟原虫如何通过调节蛋白质输出到宿主红细胞和营养摄取途径来适应胎盘微环境。总之,我们已经确定了介导可能导致妊娠并发症的急性胎盘炎症反应的细胞网络和信号通路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Acute response to pathogens in the early human placenta at single-cell resolution

Acute response to pathogens in the early human placenta at single-cell resolution

The placenta is a selective maternal-fetal barrier that provides nourishment and protection from infections. However, certain pathogens can attach to and even cross the placenta, causing pregnancy complications with potential lifelong impacts on the child’s health. Here, we profiled at the single-cell level the placental responses to three pathogens associated with intrauterine complications—Plasmodium falciparum, Listeria monocytogenes, and Toxoplasma gondii. We found that upon exposure to the pathogens, all placental lineages trigger inflammatory responses that may compromise placental function. Additionally, we characterized the responses of fetal macrophages known as Hofbauer cells (HBCs) to each pathogen and propose that they are the probable niche for T. gondii. Finally, we revealed how P. falciparum adapts to the placental microenvironment by modulating protein export into the host erythrocyte and nutrient uptake pathways. Altogether, we have defined the cellular networks and signaling pathways mediating acute placental inflammatory responses that could contribute to pregnancy complications.

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来源期刊
Cell Systems
Cell Systems Medicine-Pathology and Forensic Medicine
CiteScore
16.50
自引率
1.10%
发文量
84
审稿时长
42 days
期刊介绍: In 2015, Cell Systems was founded as a platform within Cell Press to showcase innovative research in systems biology. Our primary goal is to investigate complex biological phenomena that cannot be simply explained by basic mathematical principles. While the physical sciences have long successfully tackled such challenges, we have discovered that our most impactful publications often employ quantitative, inference-based methodologies borrowed from the fields of physics, engineering, mathematics, and computer science. We are committed to providing a home for elegant research that addresses fundamental questions in systems biology.
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