糖尿病、高血压和动脉粥样硬化中的空泡 H+-ATP 酶

IF 1.9 4区 医学 Q3 HEMATOLOGY
Na Wang, Liwei Ren, A. H. Jan Danser
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引用次数: 0

摘要

空泡 H+-ATPase(V-ATPase)是一种多亚基蛋白复合体,几乎存在于所有真核细胞中。它起着质子泵的作用,因此负责调节溶酶体、内体和细胞外空间的 pH 值。此外,V-ATP 酶还与受体介导的信号传导有关。尽管已有大量研究探讨了 V-ATPase 在癌症、骨质疏松症和神经退行性疾病中的作用,但有关其参与血管疾病的研究仍然有限。血管疾病对人类健康构成重大挑战。本综述旨在阐明 V-ATP 酶在高血压和动脉粥样硬化中的作用。此外,鉴于血管并发症是糖尿病的主要并发症,本综述还讨论了 V-ATP 酶可能导致此类并发症的途径。本综述首先概述了 V-ATPase 在高血压、动脉粥样硬化和糖尿病中的结构和功能,最后探讨了靶向 V-ATPase 的药理潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Vacuolar H+-ATPase in Diabetes, Hypertension, and Atherosclerosis

Vacuolar H+-ATPase in Diabetes, Hypertension, and Atherosclerosis

Vacuolar H+-ATPase (V-ATPase) is a multisubunit protein complex which, along with its accessory proteins, resides in almost every eukaryotic cell. It acts as a proton pump and as such is responsible for regulating pH in lysosomes, endosomes, and the extracellular space. Moreover, V-ATPase has been implicated in receptor-mediated signaling. Although numerous studies have explored the role of V-ATPase in cancer, osteoporosis, and neurodegenerative diseases, research on its involvement in vascular disease remains limited. Vascular diseases pose significant challenges to human health. This review aimed to shed light on the role of V-ATPase in hypertension and atherosclerosis. Furthermore, given that vascular complications are major complications of diabetes, this review also discusses the pathways through which V-ATPase may contribute to such complications. Beginning with an overview of the structure and function of V-ATPase in hypertension, atherosclerosis, and diabetes, this review ends by exploring the pharmacological potential of targeting V-ATPase.

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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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