Ye Tao, Kaige Guo, Hao Chen, Guobing Yan and Ming Guo
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Site-selective C(sp3)–H functionalization of primary aliphatic amines
C–H bond functionalization represents one of the most efficient and straightforward strategies for diversifying existing molecules. The most challenging task to achieve is the site-selective C(sp3)–H functionalization of primary aliphatic amines in modern organic synthesis, which has received much attention in recent years. On the one hand, the combining of photoredox catalysis (PC) and hydrogen atom transfer (HAT) for α-C(sp3)–H functionalization has been achieved via a free radical pathway. On the other hand, significant progress has also been made in native amine-directed γ- and δ-C(sp3)–H functionalization catalyzed by palladium catalysts. In this review, we systematically summarize the site-selective C(sp3)–H functionalization of primary aliphatic amines, as well as discuss the mechanisms.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.