初级脂肪族胺的 C(sp3)-H 位点选择性官能化

IF 4.7 1区 化学 Q1 CHEMISTRY, ORGANIC
Ye Tao, Kaige Guo, Hao Chen, Guobing Yan and Ming Guo
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引用次数: 0

摘要

C-H 键官能化是使现有分子多样化的最有效、最直接的策略之一。在有机合成中,实现无保护伯脂肪族胺的位点选择性 C(sp3)-H 官能化是最具挑战性的任务,近年来受到越来越多的关注。一方面,人们通过自由基途径实现了光氧化催化(PC)和氢原子转移(HAT)相结合的 α-C(sp3)-H 功能化。另一方面,钯催化剂催化的原生定向 γ 和 δ-C(sp3)-H 功能化也取得了重大进展。在这篇综述中,我们系统地总结了未受保护的脂肪族伯胺的位点选择性 C(sp3)-H 功能化,并讨论了它们的机理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Site-selective C(sp3)–H functionalization of primary aliphatic amines

Site-selective C(sp3)–H functionalization of primary aliphatic amines

C–H bond functionalization represents one of the most efficient and straightforward strategies for diversifying existing molecules. The most challenging task to achieve is the site-selective C(sp3)–H functionalization of primary aliphatic amines in modern organic synthesis, which has received much attention in recent years. On the one hand, the combining of photoredox catalysis (PC) and hydrogen atom transfer (HAT) for α-C(sp3)–H functionalization has been achieved via a free radical pathway. On the other hand, significant progress has also been made in native amine-directed γ- and δ-C(sp3)–H functionalization catalyzed by palladium catalysts. In this review, we systematically summarize the site-selective C(sp3)–H functionalization of primary aliphatic amines, as well as discuss the mechanisms.

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来源期刊
Organic Chemistry Frontiers
Organic Chemistry Frontiers CHEMISTRY, ORGANIC-
CiteScore
7.90
自引率
11.10%
发文量
686
审稿时长
1 months
期刊介绍: Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
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