先天性淋巴细胞在抗病毒防御中的组织特异性特征

IF 21.8 1区医学 Q1 IMMUNOLOGY

Cellular &Molecular Immunology Pub Date : 2024-04-29 DOI:10.1038/s41423-024-01161-x

Sytse J. Piersma

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引用次数: 0

摘要

先天性淋巴细胞（ILCs）能对入侵的病原体和癌症迅速做出反应并提供保护。先天性淋巴细胞包括自然杀伤（NK）细胞、ILC1、ILC2、ILC3 和淋巴组织诱导（LTi）细胞，并包括 I 型、II 型和 III 型免疫细胞。NK 细胞在抗病毒免疫中的作用已得到广泛认可，而其他 ILC 亚型也正在成为抗病毒防御中的角色。每个 ILC 亚型都具有特殊的功能，根据组织微环境的不同，对宿主的抗病毒免疫和健康产生独特的影响。本综述将重点介绍每种 ILC 亚型的特殊功能及其在不同组织的抗病毒免疫反应中的作用。将重点介绍易感染组织中的几种病毒，以概述组织内 ILC 免疫的程度，并强调常见反应与病毒特异性反应的区别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Tissue-specific features of innate lymphoid cells in antiviral defense

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Tissue-specific features of innate lymphoid cells in antiviral defense

Innate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells and include type I, type II, and type III immune cells. While NK cells have been well recognized for their role in antiviral immunity, other ILC subtypes are emerging as players in antiviral defense. Each ILC subset has specialized functions that uniquely impact the antiviral immunity and health of the host depending on the tissue microenvironment. This review focuses on the specialized functions of each ILC subtype and their roles in antiviral immune responses across tissues. Several viruses within infection-prone tissues will be highlighted to provide an overview of the extent of the ILC immunity within tissues and emphasize common versus virus-specific responses.

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来源期刊

Cellular &Molecular Immunology 医学-免疫学

CiteScore

31.20

自引率

1.20%

发文量

903

审稿时长

1 months

期刊介绍： Cellular & Molecular Immunology, a monthly journal from the Chinese Society of Immunology and the University of Science and Technology of China, serves as a comprehensive platform covering both basic immunology research and clinical applications. The journal publishes a variety of article types, including Articles, Review Articles, Mini Reviews, and Short Communications, focusing on diverse aspects of cellular and molecular immunology.