动态 DNA 序列的基因组频率与哺乳动物的寿命

IF 2.6 4区医学 Q2 GENETICS & HEREDITY

Cancer Genomics & Proteomics Pub Date : 2024-04-27 DOI:10.21873/cgp.20443

Marianna Martella, Nadia Carlesso, Zoë A E Waller, Guido Marcucci, Flavia Pichiorri, Steven S Smith

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引用次数: 0

摘要

动态 DNA 序列（即能够形成发夹、G-四重链、i-motifs 和三重螺旋的序列）可导致复制压力和相关突变。人类 DNA 中的 RACK7 基因就是这种序列的一个例子。由于该序列在中性 pH 下会形成 i-motif 结构，从而导致复制压力，并导致前列腺癌细胞中的自发缺失，因此我们最初的目的是确定它作为前列腺癌生物标志物的潜在用途。

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Genomic Frequencies of Dynamic DNA Sequences and Mammalian Lifespan.

Dynamic DNA sequences (i.e. sequences capable of forming hairpins, G-quadruplexes, i-motifs, and triple helices) can cause replication stress and associated mutations. One example of such a sequence occurs in the RACK7 gene in human DNA. Since this sequence forms i-motif structures at neutral pH that cause replication stress and result in spontaneous deletions in prostate cancer cells, our initial aim was to determine its potential utility as a biomarker of prostate cancer.

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来源期刊

Cancer Genomics & Proteomics ONCOLOGY-GENETICS & HEREDITY

CiteScore

5.00

自引率

8.00%

发文量

期刊介绍： Cancer Genomics & Proteomics (CGP) is an international peer-reviewed journal designed to publish rapidly high quality articles and reviews on the application of genomic and proteomic technology to basic, experimental and clinical cancer research. In this site you may find information concerning the editorial board, editorial policy, issue contents, subscriptions, submission of manuscripts and advertising. The first issue of CGP circulated in January 2004. Cancer Genomics & Proteomics is a journal of the International Institute of Anticancer Research. From January 2013 CGP is converted to an online-only open access journal. Cancer Genomics & Proteomics supports (a) the aims and the research projects of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH and (b) the organization of the INTERNATIONAL CONFERENCES OF ANTICANCER RESEARCH.