IgG4相关疾病伴新月体肾小球肾炎病例：一种不寻常的疾病表现

IF 0.8 4区医学 Q4 UROLOGY & NEPHROLOGY

Iranian journal of kidney diseases Pub Date : 2024-04-25 DOI:10.5254/dt6zs176

Azin Ghaffari, Mitra Mehrazma, Shahrzad Ossareh

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引用次数: 0

摘要

IgG4 相关疾病（IgG4-RD）是一种慢性全身性炎症性疾病，以淋巴细胞和分泌 IgG4 的浆细胞的组织浸润为特征，表现为不同组织的纤维化，通常只对口服类固醇治疗有反应。肾脏是最常受累的器官，表现为肾功能不全、肾小管间质性肾炎和肾小球肾炎。在此，我们描述了一名急性肾功能不全患者，该患者出现水肿、虚弱、贫血和多发性淋巴结病变。肾脏和淋巴结活检显示，肾脏出现新月体性肾小球肾炎，淋巴结出现淋巴浆细胞浸润。经过一个疗程的皮质类固醇和环磷酰胺静脉脉冲治疗后，患者症状缓解，肾功能改善。DOI: 10.52547/ijkd.7788.

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Case of IgG4-related Disease with Crescentic Glomerulonephritis: An Unusual Presentation of the Disease.

IgG4-related disease (IgG4-RD) is a chronic systemic inflammatory disease, characterized by tissue infiltration of lymphocytes and IgG4-secreting plasma cells, presenting by fibrosis of different tissues, which is usually responsive only to oral steroids therapy. Kidneys are the most commonly involved organs, exhibiting renal insufficiency, tubulointerstitial nephritis, and glomerulonephritis. Here, we describe a patient with acute renal insufficiency who was presented with edema, weakness, anemia and multiple lymphadenopathies. Kidney and lymph node biopsy showed crescentic glomerulonephritis in kidneys and lymphoplasmacytic infiltration in lymph nodes. After a course of treatment with an intravenous pulse of corticosteroid and cyclophosphamide, the patient's symptoms subsided, and kidney function improved. DOI: 10.52547/ijkd.7788.

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来源期刊

Iranian journal of kidney diseases UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.